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ProteomicsSac1 degron A431 cells 3h DMSO vs 3h IAA
Sac1 is a conserved phosphoinositide phosphatase, whose loss-of-function compromises cell and organism viability. Here, we employed acute auxin-inducible Sac1 degradation to identify its immediate downstream effectors in human cells. Most of Sac1 was is degraded in ~1 h, paralleled by increased PI(4...
ORGANISM(S): Homo sapiens (Human) 
2025-07-08 | PXD065794 | Pride
Human a431 cells Sac1 Auxin inducible degradation 
ProteomicsInteraction protoemics of Dictyostelium discoideum GFP-SAC1
Label free interaction protoemics of Dictyostelium discoideum GFP-SAC1 compared to GFP expressing cells
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2023-12-01 | PXD039848 | Pride
Ip-ms Sac1 Dictyostelium 
ProteomicsSac1 interaction proteomics of ALFA Sac1 and mutants
Sphingolipids are structural membrane components that also function in cellular stress responses. The serine palmitoyl-transferase (SPT) catalyzes the rate limiting step in sphingolipid biogenesis. Its activity is tightly regulated through multiple bind-ing partners, including Tsc3, Orm proteins, ce...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-10-24 | PXD044586 | Pride
Sac1  s. cerevisiae  proteomics 
ProteomicsInteraction proteomics of yeast Sac1-ALFA
Interaction proteomics of yeast Sac1-ALFA compared to untagged control strains
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-12-01 | PXD039849 | Pride
Sac1 Silac Ipms 
UnknownSac1 links phosphoinositide turnover to cryptococcal virulence.
Not available
S-EPMC10827209 | biostudies-literature
UnknownSac1 links phosphoinositide turnover to cryptococcal virulence.
Not available
S-EPMC11323556 | biostudies-literature
UnknownThe first transmembrane domain of lipid phosphatase SAC1 promotes Golgi localization.
Not available
S-EPMC3731292 | biostudies-literature
UnknownAllosteric activation of the phosphoinositide phosphatase Sac1 by anionic phospholipids.
Not available
S-EPMC3329130 | biostudies-literature
UnknownPhosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum.
Not available
S-EPMC4485137 | biostudies-literature
UnknownCellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1.
Not available
S-EPMC7353163 | biostudies-literature
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