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ProteomicsSubcellular proteomics of FLT3-ITD cells
In acute myeloid leukemia (AML), the insertion site of internal tandem duplications (ITDs) within the FLT3 gene critically determines the sensitivity to tyrosine kinase inhibitors (TKIs). Despite recent advances, patients harboring ITDs in the tyrosine kinase domain (TKD) still lack effective therap...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD073478 | Pride
Aml Flt3-itd Fractions 
ProteomicsPhosphoproteomics reveals a crucial role of FLT3 in BCR::ABL1 independent resistant chronic myeloid leukemia
BCR::ABL1 drives chronic myeloid leukemia (CML) pathology and treatment, as revealed by the success of tyrosine kinase inhibitor (TKI) therapy. However, additional poorly characterized molecular mechanisms, acting independently of BCR::ABL1, play crucial roles in CML, contributing to leukemic stem ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056957 | Pride
Leukemia Flt3 
ProteomicsMS-based phosphoproteomic of cytarabine-treated FLT3-ITD cells
ITD mutations in the FLT3 gene occur in the 30% of acute myeloid leukemia patients. The integration of ITD in the tyrosine kinase domain (TKD-ITD) of the FLT3 receptor has been shown to confer resistance to standard chemotherapy treatment. We applied state-of-the-art, high-sensitive, mass spectromet...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD038638 | Pride
Ms-based phosphoproteomic Aml resistance Chemotherapy 
ProteomicsKinase inhibition rewires the HLA-I immunopeptidome in Chronic Myeloid Leukemia
Antileukemia immunity is essential for disease control and maintaining treatment-free remission in chronic myeloid leukemia (CML). Immunotherapeutic approaches hold significant promise for enhancing immune-mediated disease control. However, successful immunotherapy relies on identifying CML-associat...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD076608 | Pride
Kinase inhibitors Immunopeptidomics Proteomics Cml 
ProteomicsGlucose-regulated and drug perturbed beta-cell phosphoproteome reveals molecular mechanisms controlling insulin secretion
Insulin-secreting beta cells play an essential role in maintaining physiological blood glucose levels, and their dysfunction leads to the development of diabetes. To elucidate the signaling events regulating insulin secretion, we applied a recently developed proteomics and phosphoproteomics workflow...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2016-12-09 | PXD003850 | Pride
Beta cells Insulin secretion Phoshoproteome Islets Systems biology 
ProteomicsFibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis
Fibro adipogenic progenitors (FAPs) promote satellite cell differentiation in adult skeletal muscle regeneration. However, in pathological conditions, FAPs are responsible for fibrosis and fatty infiltrations. Here we show that the NOTCH pathway negatively modulates FAP differentiation both in vitro...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-24 | PXD014195 | Pride
Adipogenesis Notch Inflammation Muscular dystrophy Myopathies Skeletal muscle regeneration Mass cytometry Fibro adipogenic progenitors Proteome 
ProteomicsCaspase-8 expression and its Src dependent phosphorylation on Tyr380 triggers NRF2 signaling activation in glioblastoma
Here we have employed quantitative mass spectrometry based phosphoproteomics and proteomics to characterise the impact of knocking-down the caspase 8 gene in glioblastoma cells. This strategy enabled the identification of the pathways and processes modulated by caspase 8.
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD060920 | Pride
Glioblastoma Src Nrf2 
UnknownEpilepsy Course and Developmental Trajectories in STXBP1-DEE.
Not available
S-EPMC9157582 | biostudies-literature
UnknownA new national survey of centers for cognitive disorders and dementias in Italy.
Not available
S-EPMC10791890 | biostudies-literature
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