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Transcriptomicsnext generation sequencing facilitates quantitative analysis of control and TKO liver transcriptomes
We used RNAseq to analyse the transcriptomes of cycling and quiescent livers from cTKO (Rblox/lox;p130lox/lox;p107?/?) and control mice. mRNA profiles of cycling and quiescent control and TKO liver tissue were generated by deep sequencing in duplicate
ORGANISM(S): Mus musculus 
2014-07-12 | E-GEOD-43631 | biostudies-arrayexpress
TranscriptomicsMouse HCC model
A mouse model of HCC has been developed based on the reported inactivation of the RB pathway in the majority of human HCC. This mouse model harbors floxed alleles of Rb and p130 genes, as well as germline mutation of the p107 gene. Various strategies to activate the activity of a Cre recombinase lea...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-19004 | biostudies-arrayexpress
ProteomicsTRANSCRIPTIONAL ACTIVATION BY E2F4 INDEPENDENT OF THE RB FAMILY
E2F transcription factors are central regulators of cell cycle progression and cell fate decisions in mammalian cells. E2F4 is a transcriptional repressor implicated in cell cycle arrest and whose repressive activity depends on its interaction with members of the RB family. E2F4 often represents the...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-04-26 | PXD008796 | Pride
Rb Pluripotency Embryonic stem cells P130 E2f4 Cell cycle P107 
UnknownBibliometric analysis of global research trends on small-cell lung cancer (2012-2021).
Not available
S-EPMC9583519 | biostudies-literature
ProteomicsThe AMBRA1 E3 ligase adaptor regulates Cyclin D protein stability
Here we describe AMBRA1 as the main regulator of Cyclin D protein degradation. We first identify AMBRA1 as the top candidate in a genome-wide CRISPR/Cas9 loss-of-function screen investigating the genetic basis of resistance to chemical CDK4/6 inhibition. AMBRA1 loss results in high protein levels of...
ORGANISM(S): Homo sapiens (Human) 
2021-07-24 | PXD021789 | Pride
Human Cancer Cyclin d Cell cycle 
GenomicsEGAS00001003685 - samples
Description not provided
EGAD00001005284 | EGA
GenomicsEGAS00001003686 - samples
Description not provided
EGAD00001005283 | EGA
GenomicsWhole Exome Sequencing of 15 Tumor/Normal pairs of inflammatory hepatocellular adenomas
The French ICGC project on liver tumors is coordinated by Pr Jessica Zucman-Rossi and funded by Inca (French Institute for Cancer). The aim of the present project is to identify the catalog of somatic and germline mutations in liver tumors. The present series corresponds to 15 Tumor/Normal pairs of ...
EGAS00001003686 | EGA
GenomicsRNA-sequençing of 21 inflammatory hepatocellular adenomas
The French ICGC project on liver tumors is coordinated by Pr Jessica Zucman-Rossi and funded by Inca (French Institute for Cancer). The aim of the present project is to identify the catalog of somatic and germline mutations in liver tumors.The present series corresponds to 21 RNA-seq of IHCA samples...
EGAS00001003685 | EGA
GenomicsFunGeST - Functional Genomics from cancer research to personalized medicine
Data Access Committee EGAC00001002924
EGAC00001002924 | EGA
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