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TranscriptomicsU937 scramble vs shHDAC2 upon SAHA (Vorinostat; suberoylanilide hydroxamic acid) treatment
Transcriptional profiling of U937 scramble vs shHDAC2 before and after SAHA treatment at 5µM concentration for 6 and 24 hours. Different Experimental Conditions: U937 scramble (U937 trasfected with empty vector) vs shHDAC2 (U937 trasfected with shHDAC2 vector), untreated and treated with SAHA at 5 ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-37529 | biostudies-arrayexpress
ProteomicsAn integrated systems biology approach reveals positive and negative effects of suberoylanilide hydroxamic acid (SAHA) on HIV reactivation from latency
Suberoylanilide hydroxamic acid (SAHA) has been assessed in clinical trials as part of a “shock and kill” strategy to cure HIV-infected patients. While it was effective at inducing expression of HIV RNA "shock" , treatment with SAHA did not result in the reduction of reservoir size "kill". We theref...
ORGANISM(S): Homo sapiens (Human) 
2015-09-10 | PXD002150 | Pride
Human Hiv latency Cd4 t-cells Saha Suberoylanilide hydroxamic acid 
TranscriptomicsExpression data from SKOV3 cells treated with SAHA or vehicle control
We performed a microarray experiment to assess SAHA-induced changes in expression of genes of the homologous recombination DNA repair pathway SKOV-3 ovarian cancer cells were treated with 1µM SAHA or vehicle-control (0.01% DMSO) for 6 or 24 hours, harvested and processed for RNA isolation. Data fo...
ORGANISM(S): Homo sapiens 
2014-03-19 | E-GEOD-53603 | biostudies-arrayexpress
TranscriptomicsGlobal mRNA expression profiling of murine primary PDAC cells following JQ1 or SAHA monotherapy as well as JQ1-SAHA combination therapy
Global mRNA expression profiles of murine primary PDAC cells following JQ1 or SAHA monotherapy as well as JQ1-SAHA combination therapy were collected using Affymetix mouse whole genome array (Mouse Genome 430A 2.0 Array) . Primary PDAC cells isolated from Ptf1aCre/+;Kras+/LSL-G12D;p53lox/lox (Kras;p...
ORGANISM(S): Mus musculus 
2015-09-20 | E-GEOD-64836 | biostudies-arrayexpress
ProteomicsEpigenetic Impairment of tumor potential of AML-derived extracellular vesicles
The biological active cargo of leukemia-derived extracellular vesicles (EVs) favours a wide variety of cancer-supportive mechanisms, including aberrant proliferative signalling, immune escape and drug resistance. However, whether and in which extent anti-neoplastic drugs affect EV cargo sorting is ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042168 | Pride
Vesicle Leukemia Tumorigenicity Epigenetic Saha 
TranscriptomicsRNA expression in MDA-MB-231 cells treated for 24h with SAHA, Pargyline, or both [HG-U133A_2]
Abnormal activities of histone lysine demethylases (KDMs) and lysine deacetylases (HDACs) are associated with aberrant gene expression in breast cancer development. However, the precise molecular mechanisms underlying the crosstalk between KDMs and HDACs in chromatin remodeling and regulation of gen...
ORGANISM(S): Homo sapiens 
2015-09-04 | E-GEOD-72688 | biostudies-arrayexpress
TranscriptomicsSAHA Rat Dental Pulp
Transcriptional response of rat dental pulp cells (DPCs) cultured with SAHA at early and late mineralisation time points Transcript profiling of DPC identified several novel genes expression induced and supressed by HDACi at 24 hrs and 14 days under mineralising conditions. SAHA induces several memb...
ORGANISM(S): Rattus norvegicus 
2015-06-16 | E-GEOD-67175 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of HCT116 colorectal carcinoma cells treated with HDAC inhibitors
Histone deacetylases (HDACs) regulate gene expression. Inhibition of class I HDACs has been shown to inhibit cancer cell growth. Largazole, a new potent HDAC inhibitor, shows strong antitumor activity, presumably by modulating transcription of cancer relevant genes. We used microarray analysis of hu...
ORGANISM(S): Homo sapiens 
2010-08-28 | E-GEOD-22061 | biostudies-arrayexpress
UnknownTargeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance.
Not available
S-EPMC1896119 | biostudies-literature
TranscriptomicsPatterns of changes in DNA global methylation following the treatment with GC/RA and with GC/RA plus AZA/SAHA in MYC amplified and BRG1 mutant lung cancer cell lines
Comprehensive characterization of the DNA methylome regulated by the treatment with glucocorticoids (GC) and retinoic acid (RA) alone and combined with AZA/SAHA and the relationship of these features with the status of BRG1 and MYC in lung cancer cell lines. MYC amplified cell lines and BRG1 mutant ...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-66087 | biostudies-arrayexpress
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