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ProteomicsReversible SAHH inhibitor protects against glomerulonephritis in lupus-prone NZB/NZW F1 mice by modulating α-actinin-4 associated skeleton organization of podocytes
Glomerulonephritis is one of the major complications and causes of death in systemic lupus erythematosus (SLE). Podocytes can be injured in many forms of glomerular disease, characteristic changes are actin cytoskeleton reorganization of involved foot process. ACTN4, encodes α-actinin-4, an actin-bi...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD010059 | Pride
Α-actinin-4 Integrin-linked kinase Podocyte injury Glomerulonephritis Sahh inhibitor Skeleton organization 
UnknownEpigenetic regulation of TXNIP-mediated oxidative stress and NLRP3 inflammasome activation contributes to SAHH inhibition-aggravated diabetic nephropathy.
Not available
S-EPMC8209273 | biostudies-literature
ProteomicsS-adenosylhomocysteine hydrolase participates in DNA methylation inheritance
DNA (cytosine-5) methyltransferase 1 (DNMT1) is essential for mammalian development and maintenance of DNA methylation following DNA replication in cells. The DNA methylation process generates S-adenosyl-L-homocysteine, a strong inhibitor of DNMT1. Here we report that S-adenosylhomocysteine hydrolas...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD006476 | Pride
Dnmt1 Sahh Cell cycle 
UnknownReversible SAHH inhibitor protects against glomerulonephritis in lupus-prone mice by downregulating renal α-actinin-4 expression and stabilizing integrin-cytoskeleton linkage.
Not available
S-EPMC6352376 | biostudies-literature
UnknownTherapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response.
Not available
S-EPMC4651227 | biostudies-literature
Methylation profilingS-adenosylhomocysteine hydrolase participates in DNA methylation inheritance
DNA (cytosine-5) methyltransferase 1 (DNMT1) is essential for mammalian development and maintenance of DNA methylation following DNA replication in cells. The DNA methylation process generates S-adenosyl-L-homocysteine, a strong inhibitor of DNMT1. Here we report that S-adenosylhomocysteine hydrolas...
ORGANISM(S): Homo sapiens 
2017-07-01 | GSE94055 | GEO
UnknownAnti-inflammatory and chondroprotective effects of the S-adenosylhomocysteine hydrolase inhibitor 3-Deazaneplanocin A, in human articular chondrocytes.
Not available
S-EPMC5526903 | biostudies-literature
UnknownInhibition of S-adenosyl-L-homocysteine hydrolase alleviates alloimmune response by down-regulating CD4+ T-cell activation in a mouse heart transplantation model.
Not available
S-EPMC7791210 | biostudies-literature
UnknownInhibition of juvenile hormone synthesis in mosquitoes by the methylation inhibitor 3-deazaneplanocin A (DZNep).
Not available
S-EPMC6733609 | biostudies-literature
UnknownStructural insight into binding mode of inhibitor with SAHH of Plasmodium and human: interaction of curcumin with anti-malarial drug targets.
Not available
S-EPMC5026646 | biostudies-literature
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