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ProteomicsInhibition of T cell activation and function by the CIN85 adaptor protein
CIN85 is ubiquitously expressed adaptor protein. In T cells, CIN85 is recruited to the TCR signaling complex and inhibit TCR signaling. To reveal the molecular function of CIN85-mediated inhibition, we performed Flag-CIN85 (CIN85dA) immuno-precipitation and identified the binding proteins. As a nega...
ORGANISM(S): Mus Musculus (mouse) 
2019-01-16 | PXD012369 | JPOST Repository
TranscriptomicsComparision of expression profile between wild-type and Slc39a13 knockout osteoblasts
In order to explore molecules whose expression is controlled by Slc39a13, we investigated gene expression profiling of primary osteoblast isolated from wild-type and Slc39a13 knockout mice. Keywords: knockout vs wild-type wild-type vs Slc39a13 knockout
ORGANISM(S): Mus musculus 
2008-11-07 | E-GEOD-10555 | biostudies-arrayexpress
TranscriptomicsDevelopment and Preclinical Efficacy of Novel Transforming Growth Factor-β1 (TGFβ1) siRNAs for Pulmonary Fibrosis
Idiopathic pulmonary fibrosis is a chronic devastating disease of unknown etiology. No therapy is currently available. A growing body of evidence supports the role of TGFβ1 as the major player in the pathogenesis of the disease. This study designed novel human- and mouse-specific siRNAs and siRNA/DN...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-28122 | biostudies-arrayexpress
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old candesartan-treated and nontreated Htra1 KO mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. Htra1-KO m...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-16 | PXD023477 | JPOST Repository
ProteomicsProteome analysis of brain vessels (the anterior cerebral artery and the middle cerebral artery) from 24-month-old Htra1 KO and wild type mice
CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy) is a hereditary cerebral small-vessel disease caused by loss of function mutations of HTRA1, which is a serine protease with a variety of targets, including extracellular matrix proteins. We isolate...
ORGANISM(S): Mus Musculus (mouse) 
2021-11-02 | PXD022298 | JPOST Repository
ProteomicsRapid and Label-Free Structural Proteomics by One-Step Swift Trypsin LiP-MS
We developed a rapid, surface-targeted limited proteolysis workflow, Swift Trypsin LiP-MS (STLiP-MS), to profile proteome-wide structural changes under near-native conditions. STLiP-MS uses a trypsin-immobilized spin column and centrifugation-controlled contact to achieve instantaneous, highly repro...
ORGANISM(S): Homo Sapiens (human) Cellular Organisms 
2026-01-05 | PXD069771 | JPOST Repository
ProteomicsAssessing Native-Liver Post-Kasai Portoenterostomy for biliary atresia through Stool Proteome Analysis
In this prospective study, we analyzed stool proteomes from four patients with well-controlled conditions, four patients with recurrent cholangitis, and three patients with prolonged jaundice but no cholangitis, all of whom had undergone Kasai portoenterostomy for biliary atresia (BA). The study als...
ORGANISM(S): Homo Sapiens (human) 
2025-09-04 | PXD055756 | JPOST Repository
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