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TranscriptomicsMicroarray analysis of strain EG4 vs. Nipponbare
In the japonica rice strain Gimbozu EG4, the DNA transposon mPing is actively transposing to attain over 1,000 copies, whereas in Nipponbare, where this element is virtually silent and has only 50 copies. To analyze the impact of such a massive amplification of transposable element on gene regulatio...
ORGANISM(S): Oryza sativa Japonica Group 
2010-06-20 | E-GEOD-15021 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of expression and DNA methylation at CpG-island-associated sense-antisense transcript loci in mouse
Sense-antisense transcript (SAT) pairs are pairs of transcripts that fully or partially overlap but are transcribed in opposite directions. Although SAT expression occurs in various species, most SAT pairs have not been examined in detail. Because our previous studies revealed some tissue specificit...
ORGANISM(S): Mus musculus 
2010-08-26 | E-GEOD-14392 | biostudies-arrayexpress
UnknownImpact of quality of life on overall work productivity impairment and activity impairment of patients with systemic lupus erythematosus: the PEONY study.
Not available
S-EPMC11751967 | biostudies-literature
TranscriptomicsDevelopment and Preclinical Efficacy of Novel Transforming Growth Factor-β1 (TGFβ1) siRNAs for Pulmonary Fibrosis
Idiopathic pulmonary fibrosis is a chronic devastating disease of unknown etiology. No therapy is currently available. A growing body of evidence supports the role of TGFβ1 as the major player in the pathogenesis of the disease. This study designed novel human- and mouse-specific siRNAs and siRNA/DN...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-28122 | biostudies-arrayexpress
TranscriptomicsIonizing radiation in GI tract of Tweak KO mice
TWEAK/Fn14 signaling may regulate the expression of genes involved in epithelial repair and mucosal inflammation. Comparing the gene signatures in WT and TWEAK KO mice will inform the biology of TWEAK/Fn14 pathway in the GI tract. Mice were treated with 3 Gy of ionizing radiation. After 6h and 24h m...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-25029 | biostudies-arrayexpress
ProteomicsThe customized mouse serum spectral library for the DIA-MS
For a comprehensive analysis of the mouse serum proteome, a customized mouse serum spectral library was constructed and utilized for quantitative analysis using DIA-MS. Our spectral library contained information on 1,106 mouse serum proteins. Creation of the spectral library was performed using Spec...
ORGANISM(S): Mus Musculus (mouse) 
2024-03-16 | PXD041889 | JPOST Repository
ProteomicsIdentification of gravity-responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data-independent acquisition mass spectrometry
Physical inactivity associated with gravity unloading, such as microgravity during spaceflight and hindlimb unloading (HU), can cause various physiological changes. In this study, we attempted to identify serum proteins whose levels fluctuated in response to gravity unloading. First, we quantitative...
ORGANISM(S): Mus Musculus (mouse) 
2024-03-16 | PXD041894 | JPOST Repository
ProteomicsIdentification of gravity-responsive proteins in mouse soleus muscle using proteomic analysis
This project is “Medical proteome analysis of osteoporosis- and bone mass-related proteins using the Kibo Japanese Experiment Module of International Space Station (ISS)”. Applying proteomic technologies, this research aims to identify proteins involved in space flight-induced osteopenia as well as ...
ORGANISM(S): Mus Musculus (mouse) 
2023-09-19 | PXD041190 | JPOST Repository
ProteomicsLFQ of 3-phosphoglyceroyl lysine peptides from WT and DJ-1 KO HeLa cells
WT or DJ-1 KO HeLa cells (n=3) were lysed in 500 μL of 6 M guanidine-HCl, 100 mM HEPES-NaOH, pH 7.5, 10 mM TCEP, and 40 mM CAA. The lysates were dissolved by heating and sonication, followed by centrifugation at 20,000 x g for 15 min at 4 ºC. The supernatants were recovered and proteins (1 mg each) ...
ORGANISM(S): Homo Sapiens (human) 
2025-05-07 | PXD063699 | JPOST Repository
ProteomicsUse of data-independent acquisition mass spectrometry to identify an objective serum indicator of the need for osteoporotic therapeutic intervention
Osteoporosis is characterized by weakened bone microstructure and loss of bone mass. Current diagnostic criteria for osteoporosis are based on the T-score, which is a measure of bone mineral density. However, osteoporotic fragility fractures can occur regardless of the T-score, underscoring the need...
ORGANISM(S): Homo Sapiens (human) 
2024-04-10 | PXD041546 | JPOST Repository
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