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MetabolomicsSalivary Multi-omics Characterization and Staging Diagnostic Model for Type 2 Diabetes with Different Stages of Periodontitis

Background: This study aims to comprehensively characterize the dynamic succession of the salivary microbiome and metabolic reprogramming in type 2 diabetes mellitus (T2DM) patients across progressive stages of periodontitis (Stage I–IV) using an integrated multi-omics approach. We specifica...

2026-05-20 | MTBLS13827 | MetaboLights
MetabolomicsSaliva metabolome and microbiome in permanent teeth caries

Metabolites are important determinants of disease progression. In this study, we conducted a case-control study to explore permanent teeth caries-related differences in salivary metabolite profiles and related changes in the composition of the oral microbiota in 200 subjects including 100 caries-...

2024-05-14 | MTBLS4569 | MetaboLights
ProteomicsFree-Flow Isoelectric Focusing for Comprehensive Separation and Analysis of Human Salivary Microbiome for Lung Cancer
Human microbiome contains billions of microorganisms that play important roles in the biological system and different diseases. Due to its complexity, conventional culture-independent technology may underestimate the value of low-abundance bacteria, which calls for a highly efficient method for its ...
ORGANISM(S): Homo Sapiens 
2021-03-10 | PXD024619 |
ProteomicsFree-Flow Isoelectric Focusing Based Metaproteomics Workflow Facilitates the Identification and Characterization of Human Salivary Microbiome for Lung Cancer
We developed a free-flow isoelectric focusing (FFIEF) based metaproteomics workflow to reduce the host interferences and enrich the low-abundant bacteria for better interpretation of salivary microbiome. We firstly tested the pretreatment module that could significantly reduce the host interferences...
ORGANISM(S): human saliva metagenome 
2022-11-17 | PXD026727 | Pride
Taxonomy-function integration Lung cancer Metaproteomics Free-flow isoelectric focusing Salivary microbiome Dysbiosis 
GenomicsTemporal stability of the salivary microbiome and its association with salivary markers of oxidative stress
Temporal stability of the salivary microbiome and its association with salivary markers of oxidative stress
PRJEB13941 | ENA
GenomicsTemporal Variability of the Salivary Microbiome
The human salivary microbiome exhibits temporal stability in bacterial diversity
PRJEB9010 | ENA
ProteomicsImpact of Polyethylene on Salivary Glands Proteome in Galleria melonella
Polyethylene pollutions are considered inert in nature and adversely affect the entire ecosystem. Larvae of greater wax moths (Galleria mellonella) have the ability to masticate and potentially biodegrade polyethylene films at elevated rates. The wax moth has been thought to metabolize PE independen...
ORGANISM(S): Galleria mellonella 
2020-03-19 | PXD016834 | Pride
Greater wax moth Polyethylene Biodegradation Salivary glands 
UnknownSalivary microbiome changes distinguish response to chemoradiotherapy in patients with oral cancer.
Not available
S-EPMC10687843 | biostudies-literature
UnknownSalivary microbiome profiles of oral cancer patients analyzed before and after treatment.
Not available
S-EPMC10403937 | biostudies-literature
GenomicsSalivary Oral Microbiome Signatures in SCN
Salivary Oral Microbiome Signatures in Severe Congenital Neutropenia
PRJEB27124 | ENA
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