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TranscriptomicsTranscription profiling of short-term cultured Myc transgenic vs. Myc transgenic Suv39h1 deficient mouse lymphoma cells with and without exposure to 100 pM of human TGF-b1
Genome-wide expression analysis was performed on RNA from short-term cultured Eµ-myc transgenic vs. Eµ-myc transgenic; Suv39h1-/- lymphoma cells with and without exposure to 100 pM of human TGF-b1 for 24 hours, with wildtype B-cells as control
ORGANISM(S): Mus musculus 
2008-02-20 | E-MEXP-1424 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouseB-cell lymphomas with defined genetic alterations in p53 or p73
Induction of apoptosis by the tumor suppressor p53 is known to protect from Myc-driven lymphomagenesis. The p53 family member p73 is also a pro-apoptotic protein, which is activated in response to oncogenes like Myc. We therefore investigated whether p73 provides a similar protection from Myc-driven...
ORGANISM(S): Mus musculus 
2008-12-05 | E-MEXP-1620 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of whole lymph node RNA from mice with different Suv39h1 genotypes
Genome-wide expression analysis was performed on RNA from whole neoplastic lymph nodes derived from individual Eµ-myc transgenic and Eµ-myc transgenic; Suv39h1-/- mice and from normal wildtype spleens as control.
ORGANISM(S): Mus musculus 
2008-02-20 | E-MEXP-1423 | biostudies-arrayexpress
GenomicsSequencing and genome-wide mapping of 146 bp mono-nucleosomal DNA from human and bovine sperm
The phenomenon of nucleosome retention in mammalian sperm chromatin is still not clarified yet. The goal of our study was to characterize the binding sites of sperm nucleosomes in the human and bovine genomes, and through this, to clarify whether nucleosome retention in sperm underlies rules of grea...
ORGANISM(S): Bos taurus 
2014-07-08 | E-GEOD-47843 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human BJ fibroblasts after LIN-9 depletion by a shRNA
Aim: identification of differentially expressed genes after LIN-9 depletion.

hTERT immortalized human BJ fibroblasts were infected with pMSCV-Blasticidin based retroviruses encoding a shRNA which targets human LIN-9 and the empty vector respectively.
After 4 days of selection total RNA ...
ORGANISM(S): Homo sapiens 
2006-11-23 | E-MEXP-752 | biostudies-arrayexpress
no omics definedTranscription profiling of primary mouse keratinocytes infected with Myc, MycV394D or control virus supernatants and treated with or without TGF beta 1 for 12 hours
Primary murine keratinocytes were infected with Myc, MycV394D or control virus supernatants and treated with or without TGF beta 1 for 12 hours. MycV394D is a Myc mutant, which does not bind Miz-1 anymore but is still able to bind to E-box sequences (Mol Cell 10:509-521, 2002).
ORGANISM(S): Mus musculus 
2005-12-20 | E-MEXP-497 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of AURKA in human neuroblastoma IMR-32 cells
IMR-32 cells were infected either with control-shRNA or one of two different AURKA-shRNA vectors to identify genes regulated after AURKA knockdown.
ORGANISM(S): Homo sapiens 
2008-06-01 | E-MEXP-1496 | biostudies-arrayexpress
TranscriptomicssiRNAi knockdown of ZBTB4 in human SH-EP cells reveals Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation
SH-EP cells were depleted for ZBTB4; Transfection of the cells were performed by oligofectamin RNAimax (Invitrogen) with siRNA smart pool (Dharmacon RNA Technologies); total RNA was isolated using RNAeasy Mini Kit (QIAGEN), preamplified, labeled with Cy3 and Cy5, respectively, and hybridized to cDNA...
ORGANISM(S): Homo sapiens 
2008-07-01 | E-MEXP-1554 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebrafish embryos injected with a morpholino targeting LIN9
TÜAB zebrafish were maintained at 28.5 °C in in 1x Danieau solution (58 mM NaCl, 0.7 mM KCl, 0.4 mM MgSO4, 0.6 mM Ca (NO3)2, 5 mM HEPES, pH 7.6, 0.0001 % Methylene blue). Morpholinos (Gene Tools, Philomath, OR) were designed against Danio rerio lin-9 homolog (Genebank accession NM_001044946). The mo...
ORGANISM(S): Danio rerio 
2009-03-28 | E-MEXP-2100 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast mutants Gal-YAH1, Gal-ATM1 and Gal-NBP35 to investigate responses to defects in cellular Fe-S protein maturation
The biogenesis of iron-sulfur proteins in eukaryotes is an essential process involving the mitochondrial iron-sulfur cluster (ISC) assembly and export machineries and the cytosolic Fe/S protein assembly (CIA) apparatus. To define the integration of Fe/S protein biogenesis into cellular homeostasis, ...
ORGANISM(S): Saccharomyces cerevisiae 
2007-12-14 | E-MEXP-1215 | biostudies-arrayexpress
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