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Long non-coding RNAs (lncRNAs) can exhibit cell-type or even cancer-type specific expression profiles, making them highly attractive as therapeutic targets. PAN cancer RNA sequencing data revealed sustained expression of the SAMMSON lncRNA in uveal melanoma (UM), the most common primary intraocular ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-04 | PXD023511 | Pride
Despite improvements in therapeutic strategies for treating breast cancers, tumor relapse and chemoresistance remain major issues in patient outcomes. Indeed, cancer cells display a metabolic plasticity allowing a quick adaptation to tumoral microenvironment and to cellular stresses induced by chemo...
ORGANISM(S): Homo sapiens 
2021-11-10 | GSE188404 | GEO
The Long Non Coding RNA SAMMSON is a regulator of chemosensitivity and metabolic orientation in doxorubicin resistant breast cancer cells
Genomics
SAMMSON promotes cancer cell fitness by enhancing concertedly mitochondrial and cytosolic protein synthesis
The goals of this study are to compare gene expression profiles between uveal melanoma cells treated with either a scrambled antisense oligonucleotide (NTC) or a SAMMSON inhibiting ASO wether or not in combination with mTOR inhibitor GDC-0349. GDC-0349 synergizes with SAMMSON ASO to further reduce c...
ORGANISM(S): Homo sapiens 
2022-09-24 | GSE184685 | GEO
RNA-seq analysis in uveal melanoma cells 92.1 and OMM1
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