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MetabolomicsUntargeted LC-MS metabolomic studies of Asteraceae species to discover inhibitors of Leishmania major dihydroorotate dehydrogenase

INTRODUCTION: Interesting data about the family Asteraceae as a new source of Leishmania major dihydroorotate dehydrogenase (LmDHODH) inhibitors are presented. This key macromolecular target for parasites causing neglected diseases catalyzes the fourth reaction of the de novo pyr...

2019-10-14 | MTBLS722 | MetaboLights
TranscriptomicsAIRE hypoexpression and transcriptome profiles correlate with thymic impairment in Down syndrome
Down syndrome (DS) patients frequently develop organ-specific autoimmune disorders, particularly endocrinopathies and coeliac disease, as well as an increased susceptibility to mucosal candidiasis. These clinical features resemble APECED (autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystroph...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-23910 | biostudies-arrayexpress
UnknownSex-Based Differences in Autologous Cell Therapy Trials in Patients With Acute Myocardial Infarction: Subanalysis of the ACCRUE Database.
Not available
S-EPMC8187782 | biostudies-literature
UnknownFrequency of HLA class I and II in an admixed Brazilian population with psoriasis.
Not available
S-EPMC12813529 | biostudies-literature
MetabolomicsUncovering the Complexity of the Yeast Lipidome by Means of nLC/NSI-MS/MS
Saccharomyces cerevisiae is a eukaryotic model organism widely used for the investigation of fundamental cellular processes and disease mechanisms. Consequently, the lipid landscape of yeast has been extensively investigated and up to this day the lipidome is considered as rather basic. Here, we use...
2021-01-08 | MTBLS2119 | MetaboLights
UnknownAnalysis of sex-based differences in clinical and molecular responses to ischemia reperfusion after lung transplantation.
Not available
S-EPMC8693497 | biostudies-literature
ProteomicsA Universal GlycoDesign for Lysosomal Replacement Enzymes to Improve Circulation Time and Biodistribution
Currently available enzyme replacement therapies for lysosomal storage diseases are limited in their effectiveness due in part to short circulation times and suboptimal biodistribution of the therapeutic enzymes. We previously engineered Chinese hamster ovary (CHO) cells to produce -galactosidase A ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-13 | PXD038783 | Pride
Glycoproteomics Lc-ms Therapeutics Orbitrap 
UnknownIncidence of primary graft dysfunction is higher according to the new ISHLT 2016 guidelines and correlates with clinical and molecular risk factors.
Not available
S-EPMC8264697 | biostudies-literature
UnknownCharacterization of perfusion decellularized whole animal body, isolated organs, and multi-organ systems for tissue engineering applications.
Not available
S-EPMC8239446 | biostudies-literature
MetabolomicsInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of membrane tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. In contrast, we reveal here a funct...
2021-05-06 | MTBLS2444 | MetaboLights
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