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MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
ProteomicsCYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death
ECL1_1173151: FLAG-IP, HEK293T transfected with pcDNA3.1 vector expressing N-term-3XFLAG tagged GFP ECL1_1173152: FLAG-IP, HEK293T transfected with pcDNA3.1 vector expressing N-term-3XFLAG tagged GFP ECL1_1173153: FLAG-IP, HEK293T transfected with pcDNA3.1 vector expressing N-term-3XFLAG tagged CYP1...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Coxiella Burnetii (ncbitaxon:777) 
2024-12-23 | MSV000096725 | MassIVE
UnknownThe sexually dimorphic impact of maltreatment on cortical thickness, surface area and gyrification.
Not available
S-EPMC5003912 | biostudies-literature
TranscriptomicsThe bile acid CoA ligase, FATP5, is necessary for NAT synthesis in the liver
This study aimed to investigate the overlap between hepatic NAT and the bile acid synthesis to identify additional enzymes involved in NAT synthesis in the liver. We sequenced livers high-fat fed mice the were either wild-type or with a single-amino acid substitution in fatty acid amide hydrolase (F...
ORGANISM(S): Mus musculus 
2026-03-02 | E-MTAB-15752 | biostudies-arrayexpress
TranscriptomicsRNA-seq of livers from mice treated for eight weeks with the glucagon receptor antibody, REGN1193, compared to mice treated with a control antibody, REGN1945, (control group)
Chronic glucagon receptor inhibition with a glucagon receptor antibody decreases amino acid catabolism and ureagenesis, while increasing plasma triglyceride concentrations, plasma very-low density lipoprotein cholesterol concentrations, and liver triglyceride concentrations. To dissect the molecular...
ORGANISM(S): Mus musculus 
2022-10-09 | E-MTAB-12048 | biostudies-arrayexpress
UnknownA theoretical study of chemical bonding and topological and electrostatic properties of the anti-leprosy drug dapsone.
Not available
S-EPMC7228959 | biostudies-literature
UnknownAdvances in Risk Classification and Treatment Strategies for Neuroblastoma.
Not available
S-EPMC4567703 | biostudies-literature
TranscriptomicsRNA-seq of livers from female mice treated for eight weeks with the glucagon analogue, NNC9204-0043, compared to female mice treated with PBS (control group)
Chronic glucagon receptor activation with a long-acting glucagon analogue increases amino acid catabolism, and to dissect the molecular mechanism underlying this effect, RNA sequencing of liver biopsies from female mice treated for eight weeks with GCGA or PBS were performed.
ORGANISM(S): Mus musculus 
2022-10-11 | E-MTAB-12040 | biostudies-arrayexpress
GenomicsZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.
The telomeric amplicon at 8p12 is common in oestrogen receptor-positive (ER+) breast cancers. Array-CGH and expression analyses of 1172 primary breast tumours revealed that ZNF703 was the single gene within the minimal amplicon and was amplified predominantly in the Luminal B subtype. Amplification ...
EGAS00000000082 | EGA
UnknownExploring the effect of UV-C radiation on earthworm and understanding its genomic integrity in the context of H2AX expression.
Not available
S-EPMC7713072 | biostudies-literature
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