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ProteomicsRetina-Targeted 17β-Estradiol by the DHED Prodrug Rescues Visual Function and Actuates Neuroprotective Protein Net-works after Optic Nerve Crush in a Rat Model of Surgical Menopause. Katalin Prokai-Tatrai, Khadiza Zaman, Ammar Kapic, Kelleigh Hogan , Gabriela Sanchez-Rodriguez, Anna E. Silverio Vien Nguyen , Laszlo Prokai and Andrew J. Feola
The association between 17β-estradiol (E2) deprivation, seen in menopause and a risk for devel-oping glaucoma, has been shown. Thus, exogenous supplementation of E2 may protect against retinal ganglion cell (RGC) degradation and vision loss. Here, we investigated the utility of topical 10β,17β-dihyd...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-05-07 | PXD059520 | Pride
Bioinformatics  dhed  estrogen  glaucoma  menopause  optic nerve crush  optomotor response  protein–protein interaction networks  quantitative label-free retina proteomics 
UnknownGM-CSF: A Double-Edged Sword in Cancer Immunotherapy.
Not available
S-EPMC9294178 | biostudies-literature
TranscriptomicsThe roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus
We investigated the roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus (DENV). Double-deficient Irf-3-/-7-/- mice infected with the DENV2 strain S221 possessed 1,000-150,000 fold higher levels of viral RNA than wild-type and single-deficient mice 24 hours after infection; how...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-49871 | biostudies-arrayexpress
UnknownAn analysis of cigarette sales during Poland's menthol cigarette sales ban: small effects with large policy implications.
Not available
S-EPMC9527965 | biostudies-literature
UnknownThe Antarctic Circumpolar Current as a diversification trigger for deep-sea octocorals.
Not available
S-EPMC4700699 | biostudies-literature
UnknownInsight into the roles of selection in speciation from genomic patterns of divergence and introgression in secondary contact in venomous rattlesnakes.
Not available
S-EPMC5468163 | biostudies-literature
UnknownMeasuring the effectiveness of protected area networks in reducing deforestation.
Not available
S-EPMC2567237 | biostudies-literature
UnknownThe unrestricted global effort to complete the COOL trial.
Not available
S-EPMC10173926 | biostudies-literature
ProteomicsA type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS
Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus induced disease 2019 (COVID-19). Neutrophils play a key role in the lung injury characteristic of non-COVID-19 A...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD023834 | Pride
Ards Type i ifn Sars-cov-2 Dexamethasone Neutrophil Covid-19 
MetabolomicsThe impact of nutritional supplementation on sweat metabolomic content
Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...
2021-03-15 | MTBLS2427 | MetaboLights
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