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ProteomicsMetabolic flexibility and expression of CD98 define the low density neutrophils mobilised in response to G-CSF
Low density neutrophils (LDN) co-purify with mononuclear cells during density-gradient separation of peripheral blood. LDN are rarely detected in healthy individuals but appear in the peripheral blood (PB) of patients with inflammatory diseases, malignancies and in individuals treated with granulocy...
ORGANISM(S): Homo sapiens (Human) 
2022-12-19 | PXD023952 | Pride
Proteogenomics G-csf Neutrophils 
ProteomicsSelective activation of PERK signaling mediates fibroblast education and tumor progression by a CRELD2-dependent mechanism
It is now well-accepted that cancers co-opt the microenvironment to support their growth. However, the molecular mechanisms underlying cancer-microenvironment interactions remain poorly defined. We have found that Rho-associated kinase (ROCK) activity in the epithelial component of mammary tumors se...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-27 | PXD018253 | Pride
Cancer progression Integrated stress response (isr) Unfolded protein response 25 (upr) Perk Cancer-associated fibroblasts (cafs) Breast cancer Endoplasmic reticulum (er)stress Rock 26 extracellular matrix Tumor microenvironment 
ProteomicsA PP2A-Integrator complex fine-tunes transcription by opposing CDK9
Gene expression by RNA Polymerase II (RNAPII) is tightly controlled by Cyclindependent kinases (CDKs) at discrete checkpoints during the transcription cycle. The RNAPII pausing checkpoint, engaged after transcription initiation, is controlled by CDK9 to regulate transcription in metazoans. We discov...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) 
2022-08-12 | PXD022962 | Pride
Cdk9 Transcription Pp2a 
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