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TranscriptomicsContribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata (part 1)
In this study, we aimed to determine genome-wide changes in gene expression driven by seven individual CgPDR1 hyperactive alleles as compared to wild-type allele to identify i) the CgPdr1p target genes differentially expressed in presence of CgPDR1 hyperactive alleles and ii) potential virulence fa...
ORGANISM(S): Candida glabrata 
2010-12-31 | E-GEOD-23827 | biostudies-arrayexpress
TranscriptomicsMilbemycins: more than efflux inhibitors for fungal pathogens
This study investigated the effect of milbemycons as efflux inhibitors and antifungal agents. Milbemycin oxims can inhibit growth of Candida glabrata and C. albicans. The effect of milbemycins on transcriptomes was inbvestigated. Gene expression was measured in C. glabrata milbemycin-treated cells (...
ORGANISM(S): Candida albicans 
2013-03-08 | E-GEOD-40232 | biostudies-arrayexpress
TranscriptomicsLoss of mitochondrial functions in Candida glabrata results in enhanced virulence in mice
Two C. glabrata related isolates recovered from the same patient undergoing azole therapy were characterized. The first isolate, BPY40, is azole-susceptibleand the second, BPY41, is azole-resistant. To determine whether the petite mutation conferred a selective advantage during host infection, the v...
ORGANISM(S): Candida glabrata 
2010-12-31 | E-GEOD-23826 | biostudies-arrayexpress
TranscriptomicsIdentification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans
The identification of novel transcription factors associated to antifungal response may allow the discovery of fungal specific targets for new therapeutic strategies. A collection of 241 C. albicans transcriptional regulators mutants was screened for altered susceptibility to fluconazole, caspofungi...
ORGANISM(S): Candida albicans 
2012-05-02 | E-GEOD-37682 | biostudies-arrayexpress
TranscriptomicsContribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata (part 2)
In this study, we aimed to determine genome-wide changes in gene expression driven by seven individual CgPDR1 hyperactive alleles as compared to wild-type allele to identify i) the CgPdr1p target genes differentially expressed in presence of CgPDR1 hyperactive alleles and ii) potential virulence fa...
ORGANISM(S): Candida glabrata 
2010-12-31 | E-GEOD-23828 | biostudies-arrayexpress
TranscriptomicsContribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata
This SuperSeries is composed of the following subset Series: GSE23827: Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata (part 1) GSE23828: Contribution of CgPDR1-regulated genes in enhanced virulence of azole-resistant Candida glabrata (part 2) Refer t...
ORGANISM(S): Candida glabrata 
2010-12-31 | E-GEOD-23829 | biostudies-arrayexpress
TranscriptomicsIn depth characterization of the activity of a novel synthetic macrocyclic antifungal compound
The systemic infections by peptogenous fungi member of the genera Candida and Aspergillus represent a serious threat for public health. During previous research we have successfully identified a family of compounds active against different Candida spp. including strains resistant to antifungal drugs...
ORGANISM(S): Candida albicans 
2015-04-01 | E-GEOD-65396 | biostudies-arrayexpress
TranscriptomicsExpression Profiling of the Response to Short-Term Exposure to Fluconazole in Cryptococcus neoformans Serotype A
Fluconazole (FLC), a triazole antifungal drug, is widely used for the maintenance therapy of cryptococcal meningoencephalitis, the most common opportunistic infection in AIDS patients, but this usage predisposes to the appearance of FLC resistance, especially in patients with no or limited access to...
ORGANISM(S): Filobasidiella neoformans 
2010-11-15 | E-GEOD-24927 | biostudies-arrayexpress
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