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TranscriptomicsMicroRNA expression profile in macrophages from rheumatoid arthritis and osteoarthritis patients
In osteoarthritis (OA) and rheumatoid arthritis (RA), many pathological alterations result from aberrant macrophage hyperactivation in the inflamed synovial membrane, and inhibition of macrophage effector functions is a therapeutic strategy in both diseases. Little is known, about the specific gene...
ORGANISM(S): Homo sapiens 
2016-02-05 | E-GEOD-63745 | biostudies-arrayexpress
MetabolomicsSubcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages
Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of multidrug therapy. Difficulty visualizing the subcellular localization of antibiotics in infected host cells means t...
2020-12-07 | MTBLS959 | MetaboLights
ProteomicsQuantitative proteomics and in-cell cross-linking reveal cellular reorganisation during early neuronal differentiation of SH-SY5Y cells
The proteomes of undifferentiated and differentiated SH-SY5Y cells are characterised and compared. For this, neuronal differentiation using retinoic acid (RA) or a combination of RA and phorbol-12-myristat-13-acetate (RA/PMA) was explored. An MS-based label-free quantification approach is applied to...
ORGANISM(S): Homo sapiens (Human) 
2022-04-08 | PXD031054 | Pride
Proteomics Chemical cross-linking Mass spectrometry Protein networks Actin Sh-sy5y 
ProteomicsRhizopus delemar LC-MS/MS high low oxygen
The R. delemar strain ATCC 20344 was cultured under nitrogen starvation conditions with varied oxygen availability to induce high (aerobic) and low (anaerobic) fumarate production.
ORGANISM(S): Rhizopus delemar 
2017-02-15 | PXD004600 | Pride
Rhizopus delemar Anaerobic Shotgun proteomics Aerobic Lc-ms/ms 
MetabolomicsDeficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease
Non-alcoholic fatty liver is the most common liver disease worldwide. Here, we show that the mitochondrial protein mitofusin 2 (Mfn2) protects against liver disease. Reduced Mfn2 expression was detected in liver biopsies from patients with non-alcoholic steatohepatitis (NASH). Moreover, reduced Mfn2...
2018-01-25 | MTBLS600 | MetaboLights
Unknown"Mushroom cloud": a giant left ventricular pseudoaneurysm after a myocardial infarction due to myocardial bridging--a case report.
Not available
S-EPMC2736930 | biostudies-literature
TranscriptomicsProtoanemonin: A new natural quorum sensing inhibitor that selectively activates iron starvation response
Many Gram-negative bacteria employ cell-to-cell communication mediated by N-acyl homoserine lactones (quorum sensing) to control expression of a wide range of genes including, but not limited to, genes encoding virulence factors. Outside the laboratory, the bacteria live in complex communities where...
ORGANISM(S): Pseudomonas aeruginosa 
2012-06-12 | E-GEOD-27674 | biostudies-arrayexpress
UnknownClinical safety and feasibility of a novel implantable neuroimmune modulation device for the treatment of rheumatoid arthritis: initial results from the randomized, double-blind, sham-controlled RESET-RA study.
Not available
S-EPMC10935935 | biostudies-literature
UnknownCoGA: An R Package to Identify Differentially Co-Expressed Gene Sets by Analyzing the Graph Spectra.
Not available
S-EPMC4551485 | biostudies-literature
UnknownHLA-DRB1*07:01 and *08:02 Alleles Confer a Protective Effect Against ACPA-Positive Rheumatoid Arthritis in a Latin American Admixed Population.
Not available
S-EPMC7765073 | biostudies-literature
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