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ProteomicsUsp25-Erlin1/2 activity limits cholesterol flux to trigger TLR3 responses and restrict a broad range of viruses
Reprogramming lipid metabolic pathways is a critical feature of activating immune responses to infection. However, how these reconfigurations are regulated, particularly during virus infections are poorly understood. Our previous screen to identify cellular deubiquitylases activated during influenza...
ORGANISM(S): Homo sapiens (Human) Influenza A virus 
2026-02-09 | PXD034797 | Pride
Deubiquitylases Lipid metabolism Interaction proteomics Antiviral immunity 
ProteomicsUCHL3 regulates subgenomic flaviviral RNA condensates to promote virus propagation
Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organised and maintained in cells remains poorly understood. Here we identify ubiquitin C-terminal hydrolase L3 (UCHL3) as a post-translational regulator of flavivirus sfRNA stability and function. Using a proximit...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD075983 | Pride
Dengue virus Flavivirus Biomolecular condensates Uchl3 Sfrna Zika virus Subgenomic rna 
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