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ProteomicsUCHL3 regulates subgenomic flaviviral RNA condensates to promote virus propagation
Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organised and maintained in cells remains poorly understood. Here we identify ubiquitin C-terminal hydrolase L3 (UCHL3) as a post-translational regulator of flavivirus sfRNA stability and function. Using a proximit...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD075983 | Pride
Dengue virus Flavivirus Biomolecular condensates Uchl3 Sfrna Zika virus Subgenomic rna 
GenomicsEffect of Zika virus (ZIKV) sfRNA on host gene expression in human brain organoids
Effect of Zika virus (ZIKV) sfRNA on host gene expression in human brain organoids
PRJNA957819 | ENA
TranscriptomicsEffect of Zika virus (ZIKV) sfRNA on host gene expression in human brain organoids
We employed 3D brain organoids generated from induced human pluripotent stem cells (ihPSC) as ex vivo model of viral infection in the developing brain and utilized wild type (WT) ZIKV producing sfRNA and mutant ZIKV deficient in production of sfRNA. Global transcriptome profiling by RNA-Seq revealed...
ORGANISM(S): Homo sapiens 
2023-04-21 | GSE230197 | GEO
GenomicsEffect of Zika virus noncoding RNA (sfRNA) on gene expression in human placental cells
Effect of Zika virus noncoding RNA (sfRNA) on gene expression in human placental cells
PRJNA720405 | ENA
TranscriptomicsEffect of Zika virus noncoding RNA (sfRNA) on gene expression in human placental cells
Transcriptome-wide gene expression profiling of cells infected with WT and sfRNA-deficient ZIKV was performed to fully map the effects of sfRNA on the entire spectrum of host antiviral responses. The human placental cell line BeWo was used for this experiment as it is known to support ZIKV replicati...
ORGANISM(S): Homo sapiens 
2022-12-07 | GSE171648 | GEO
ProteomicsZIKV and DENV-2 sfRNA RNA Pull down Hela extract LC-MSMS
Insect-borne flaviviruses produce a 300-500 base long noncoding RNA, termed sfRNA, by stalling the cellular 5’-3’ exoribonuclease XRN1 via structures located in their 3’ untranslated regions. In this study we demonstrate that the production of sfRNAs by Zika virus results in the repression of XRN1 ...
ORGANISM(S): Homo sapiens (Human) 
2019-10-01 | PXD014933 | Pride
Zikv Lc-msms Hela extract Denv-2 Sfrna 
UnknownThe structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production.
Not available
S-EPMC4163914 | biostudies-literature
UnknownFlavivirus sfRNA suppresses antiviral RNA interference in cultured cells and mosquitoes and directly interacts with the RNAi machinery.
Not available
S-EPMC4619171 | biostudies-literature
UnknownSubgenomic flavivirus RNA (sfRNA) associated with Asian lineage Zika virus identified in three species of Ugandan bats (family Pteropodidae).
Not available
S-EPMC8052318 | biostudies-literature
UnknownZika virus dumbbell-1 structure is critical for sfRNA presence and cytopathic effect during infection.
Not available
S-EPMC10470596 | biostudies-literature
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