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ProteomicsSeptin 7 Interacts With Numb To Preserve Sarcomere Structural Organization And Muscle Contractile Function
Here, we investigated mechanisms by which aging-related reductions of the levels of Numb in skeletal muscle fibers contribute to loss of muscle strength and power, two critical features of sarcopenia. Numb is an adaptor protein best known for its critical roles in development including asymmetric ce...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-04-28 | MSV000089327 | MassIVE
TranscriptomicsEffect of 5-azacytidine on gene expression in C2C12 myoblasts
Mesenchymal progenitor cells can be differentiated in vitro into myotubes that exhibit many characteristic features of primary mammalian skeletal muscle fibers. However, in general, they do not show the functional excitation-contraction coupling or the striated sarcomere arrangement typical of matur...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-30192 | biostudies-arrayexpress
UnknownInvestigating the correlation of muscle function tests and sarcomere organization in C. elegans.
Not available
S-EPMC8362255 | biostudies-literature
UnknownSmyd1 is essential for myosin expression and sarcomere organization in craniofacial, extraocular, and cardiac muscles.
Not available
S-EPMC9234968 | biostudies-literature
UnknownVagus nerve stimulation optimized cardiomyocyte phenotype, sarcomere organization and energy metabolism in infarcted heart through FoxO3A-VEGF signaling.
Not available
S-EPMC7665220 | biostudies-literature
TranscriptomicsThe AP-1 Transcription Factor c-Jun Prevents Stress-Imposed Maladaptive Remodeling of the Heart
Systemic hypertension increases cardiac workload and subsequently induces signaling networks in heart that underlie myocyte growth (hypertrophic response) through expansion of sarcomeres with the aim to increase contractility. However, conditions of increased workload can induce both adaptive and ma...
ORGANISM(S): Mus musculus 
2013-09-19 | E-GEOD-47898 | biostudies-arrayexpress
UnknownPlakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization.
Not available
S-EPMC8519574 | biostudies-literature
GenomicsAlpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle
Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle
PRJNA889737 | ENA
TranscriptomicsAlpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle 
Muscle contraction is driven by the molecular machinery of the sarcomere. While the constituent components of the sarcomere are well characterized, it is less clear how the activity and turnover of sarcomeric proteins is regulated. In particular, phosphorylation is critical regulator of muscle funct...
ORGANISM(S): Homo sapiens 
2023-01-10 | GSE215304 | GEO
UnknownA Region of UNC-89 (Obscurin) Lying between Two Protein Kinase Domains Is a Highly Elastic Spring Required for Proper Sarcomere Organization.
Not available
S-EPMC9549344 | biostudies-literature
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