Sort   by:  
 Page size 
ProteomicsA Conformation specific Nanobody Targeting the NMN-activated State of SARM1
Upon axonal injury, Sterile alpha (SAM) and Toll/interleukin-1 receptor (TIR) motif containing 1 (SARM1) is activated by nicotinamide mononucleotide (NMN) to deplete NAD and consequently promote the process of axon degeneration (AxD). Currently, only the inactive form of SARM1 in its auto-inhibitory...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD033528 | Pride
Sarm1 Adp ribosyl cyclase Xl-ms Hdx-ms 
GenomicsMacrophage depletion blocks congenital SARM1-dependent neuropathy
Macrophage depletion blocks congenital SARM1-dependent neuropathy
PRJNA865584 | ENA
ProteomicsSelective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain
The NAD hydrolase (NADase) SARM1 acts as a central executioner of programmed axon death and is a possible therapeutic target for neurodegenerative disorders. While orthosteric inhibitors of SARM1 have been described, this multi-domain enzyme is also subject to intricate forms of autoregulation, sugg...
ORGANISM(S): Homo sapiens (Human) 
2022-08-22 | PXD035400 | Pride
Covalent Chemical proteomics Allosteric inhibition Axonopathy Neurodegeneration 
GenomicsSarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy
Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy
PRJNA1059265 | ENA
GenomicsEffect of SARM1 deficiency on mouse brain transcriptome with or without prion infection
Effect of SARM1 deficiency on mouse brain transcriptome with or without prion infection
PRJNA514338 | ENA
TranscriptomicsMacrophage depletion blocks congenital SARM1-dependent neuropathy
Axon loss contributes to many common neurodegenerative disorders. In healthy axons, the axon survival factor NMNAT2 inhibits SARM1, the central executioner of programmed axon degeneration. We identified two rare NMNAT2 missense variants in two brothers afflicted with a progressive neuropathy syndrom...
ORGANISM(S): Mus musculus 
2022-10-25 | GSE210403 | GEO
GenomicsLoss of Sarm1 Mitigates Axonal Degeneration and Promotes Neuronal Regeneration After Ischemic Stroke
Loss of Sarm1 Mitigates Axonal Degeneration and Promotes Neuronal Regeneration After Ischemic Stroke
PRJNA1180930 | ENA
UnknownDeubiquitination of SARM1 by USP13 regulates SARM1 activation and axon degeneration.
Not available
S-EPMC11749472 | biostudies-literature
UnknownSARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice.
Not available
S-EPMC10113485 | biostudies-literature
GenomicsscRNA-seq of wild type and Sarm1-/- GBM mouse models
scRNA-seq of wild type and Sarm1-/- GBM mouse models
PRJNA1116126 | ENA
Sort   by:  
 Page size