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TranscriptomicsGene expression profile of murine intestinal epithelial cells after RANKL treatment
RANKL (receptor acrivator of NFkB ligand) is a member of TNF superfamily cytokines. In the gastrointestinal tract, RANKL is expressed in the stromal cells of Peyer's patches, and involved in the development of the specialized intestinal epithelial cells, called M cells. To identify the genes involve...
ORGANISM(S): Mus musculus 
2012-06-16 | E-GEOD-37861 | biostudies-arrayexpress
TranscriptomicsIncomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse
Mammals have evolved a mechanism to compensate for the difference in the number of X chromosome genes between XX females and XY males by inactivating one of the two X chromosomes in females. This X chromosome inactivation phenomenon is triggered by Xist gene, which is essential for X-inactivation to...
ORGANISM(S): Mus musculus 
2011-03-30 | E-GEOD-27373 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for knockdown of synthetic lethal gene
We performed genome-wide expression profiling analysis to define the genes underlying the synthetic-lethal relationship between CBP and p300. We extracted 1,936 genes whose expression levels changed >2-fold upon p300-knockdown (KD) in CBP-KO cells, or upon CBP-KD in p300-KO cells, but not in either ...
ORGANISM(S): Homo sapiens 
2015-12-12 | E-GEOD-73682 | biostudies-arrayexpress
TranscriptomicsIdentification of targets specifically regulated by a 'super hybrid p53'
p63, like its homologue, the tumor suppressor p53, is also able to induce apoptosis in several cancer cell types. p53 family proteins are composed of three characteristic domains which are: 1) an N-terminal transactivation domain (TAD); 2) a central DNA-binding domain (DBD); and 3) an oligomerizatio...
ORGANISM(S): Homo sapiens 
2012-02-04 | E-GEOD-35512 | biostudies-arrayexpress
TranscriptomicsGene expression signatures in HuH7 cells transfected with super hybrid p53 version 2.
The p53 tumor suppressor belongs to a gene family that includes two other structurally and functionally related members: p63 and p73. However, the regulation of p53 activity differs significantly from that of p73 and p63. To enhance the tumor suppressive activity of p53, we created a p63/p53 hybrid ...
ORGANISM(S): Homo sapiens 
2013-05-23 | E-GEOD-42493 | biostudies-arrayexpress
TranscriptomicsGenes regulated by miR-34b/c and DAC
We found frequent epigenetic silencing of microRNA-34b/c in human colorectal cancer. Introduction of miR-34b/c into a colorectal cancer cell line induced significant changes in gene expression profile. We also found overlap between the genes downregulated by miR-34b/c and those downregulated by DAC....
ORGANISM(S): Homo sapiens 
2008-04-30 | E-GEOD-10455 | biostudies-arrayexpress
UnknownDecreased Abundance of Genus Slackia in Individuals With Obesity and Colorectal Adenoma.
Not available
S-EPMC11330935 | biostudies-literature
TranscriptomicsAnalysis of small RNAs in piRNA pathway mutant mouse testes
Piwi-interacting RNAs are 25-32 nt small RNAs bound to Piwi proteins. To know the steps where factors involved in the piRNA biogenesis (MILI, MIWI2, ZUC (MitoPLD), MVH) work, we sequenced small RNAs from mutant mouse testes and analyzed piRNAs. Examination of small RNAs in testes of mutant mouse
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20327 | biostudies-arrayexpress
TranscriptomicsGene expression data of human dermal pilla cells, human induced pluripotent stem cell-derived CD271+CD90+ mesenchymal stem cells before and after the induction toward dermal papilla cells
To assess if human induced pluripotent stem cell-derived mesenchymal stem cells (hiPSC-MSCs) could be induce to acquire dermal papilla (DP) properties (especially hair inductive capacity), hiPSCs were initially programmed in serum-free MSC medium with FGF, TGFbeta and PDGF. Subsequently, hiMSCs wer...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-61511 | biostudies-arrayexpress
UnknownCommunity-Level Compact City Design, Health Care Provision, and Outcomes of Patients With Stroke.
Not available
S-EPMC12449981 | biostudies-literature
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