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TranscriptomicsLeucegene
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-48173 | biostudies-arrayexpress
TranscriptomicsTranscriptome of Primitive Human Hematopoietic Cells: A New Resource to Find hHSC-Specific Genes
We analysed the transcriptome of different HSC-enriched subpopulations of cells sorted from human umbilical cord blood and isolated from several individuals with different genetic backgrounds. We aim at identifying new cell surface markers associated with human HSC and downstream mature hematopoieti...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-48846 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of primary AML specimens exposed to AhR modulating agents
The goal of the study was to identify genes that are directly or indirectly coregulated by the AhR pathway in primary human AML cells. Patient AML cells were treated for 16 hours with the two indirubin derivatives 6-bromoindirubin-3'oxime (BIO), 1-Methyl-6-bromoindirubin-3'oxime (MeBIO), the AHR-ant...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-48843 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of human adult peripheral blood populations
Generate transcriptomic atlas of healthy peripheral blood subpopulations RNA-Seq performed on sorted granulocytes, monocytes, B-cells, T-cells, total WBC, CD34+ cells Leucegene Project, IRIC
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-51984 | biostudies-arrayexpress
ProteomicsDDB1 engagement defines the selectivity of S656 analogs for cyclin K degradation over CDK inhibition
In efforts to identify additional therapeutic targets for Acute Myeloid Leukemia (AML), we performed a high-throughput screen that includes 56 primary specimens tested with 10,000 structurally diverse small molecules. One specific hit, called S656 acts as a molecular glue degrader (MGD), that mediat...
ORGANISM(S): Homo sapiens (Human) 
2025-03-18 | PXD061850 | Pride
Molecular glue degrader Cdk12 Ddb1 Cyclin k Acute myeloid leukemia 
TranscriptomicsTranscriptome data of CD34+ human cord blood-derived cell treated with UM171, SR1 or both
mRNA profiling of CD34+ human cord blood-derived cell treated with UM171, SR1 or both mRNA profiles of CD34+ human cord blood-derived cell treated with DMSO (control), SR1 [500nM], UM171 [35nM] or combination SR1 [500nM]+ UM171 [35nM] for 30min, 3hr, 12hr, 24hr, 48hr, 72hr were generated by deep s...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-57299 | biostudies-arrayexpress
TranscriptomicsRNA expression profiling of human mPB or CB-derived CD34+ cells treated with UM171 at different doses
RNASeq data for mPB or CB-derived CD34+ exposed to UM171 human mobilized peripheral blood or cord blood-derived CD34(+) cells were cultured for 16 hours with vehicle (DMSO), dose response of UM171 [11.9nM, 19nM, 30.5nM, 48.8nM, 78.1nM and 125nM], SR1 [500nM] and combination of( UM171 [48.8nM]+SR1 ...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-57561 | biostudies-arrayexpress
TranscriptomicsLeucegene: ALL sequencing
RNA sequencing of human leukemia The goals of this project are to obtain a comprehensive study of mutations and gene expression in human T ALL (acute lymphoblastic leukemia). Methods: T ALL cells were thawed. DNA and RNA (polyA) was extracted and sequences were obtained with an Illumina HiSeq 2000 s...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-49601 | biostudies-arrayexpress
TranscriptomicsLeucegene: AML sequencing
RNA sequencing of human leukemia The goals of this project are to obtain a comprehensive study of mutations and gene expression in human acute myeloid leukemia (AML). Methods: AML cells were thawed. DNA and RNA (polyA) was extracted and sequences were obtained with an Illumina HiSeq 2000 sequencer.
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-49642 | biostudies-arrayexpress
TranscriptomicsRNAi profiling by array of mouse hematopoietic stem cells infect ed with shPRox1 or shLuciferase
Global gene expression profiles of shProx1 vs. shLuciferase infected mouse hematopoietic stem cells.
ORGANISM(S): Mus musculus 
2010-08-01 | E-MTAB-290 | biostudies-arrayexpress
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