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TranscriptomicsGenomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns
CHD7 is a member of the chromodomain helicase DNA binding domain family of ATP-dependent chromatin remodeling enzymes. De novo mutation of the CHD7 gene is a major cause of CHARGE syndrome, a genetic disease characterized by a complex constellation of birth defects. To gain insight to the function...
ORGANISM(S): Mus musculus 
2009-01-22 | E-GEOD-14460 | biostudies-arrayexpress
TranscriptomicsNHGRI Menin ChIP-Chip
Multiple endocrine neoplasia type I (MEN1) is a familial cancer syndrome characterized primarily by tumors of multiple endocrine glands. The gene for MEN1 encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to interact with several components of a trithor...
ORGANISM(S): Homo sapiens 
2006-07-24 | E-GEOD-5357 | biostudies-arrayexpress
TranscriptomicsEpigenomic enhancer profiling defines a signature of colon cancer
This SuperSeries is composed of the following subset Series: GSE36204: Epigenomic enhancer profiling defines a signature of colon cancer [ChIP-seq] GSE36400: All exon array expression data in normal colon and primary colon cancer lines [expression] Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-04-15 | E-GEOD-36401 | biostudies-arrayexpress
GenomicsCHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.
Gene expression changes were measured between mouse ES cells of three genotypes: WT Chd7, Heterzygous Chd7 Null, Homozygous Chd7 Null. The hypothesis being tested was that CHD7, a chromatin remodeling protein, functions as a transcriptional regulator. This experiment was performed to detect gene t...
ORGANISM(S): Mus musculus 
2010-06-15 | E-GEOD-22341 | biostudies-arrayexpress
TranscriptomicsAll exon array expression data in normal colon and primary colon cancer lines [expression]
Cancer is characterized by gene expression aberrations. Studies have largely focused on coding sequences and promoters, despite the fact that distal regulatory elements play a central role in controlling transcription patterns. Here we utilize the histone mark H3K4me1 to analyze gain and loss of en...
ORGANISM(S): Homo sapiens 
2012-04-15 | E-GEOD-36400 | biostudies-arrayexpress
TranscriptomicsSystematic evaluation of variability in simulated ChIP-chip experiments
The most widely-used method for detecting and measuring genome-wide protein-DNA interactions is chromatin immunoprecipitation on tiling microarrays, commonly known as ChIP-chip. Many tiling array platforms, amplification methods, and analysis algorithms exist for ChIP-chip, but a rigorous assessment...
ORGANISM(S): Homo sapiens 
2008-01-31 | E-GEOD-9842 | biostudies-arrayexpress
Genomicsena-DATASET-dkfz_b062-21-02-2018-14:40:33:479-591 - samples
This dataset contains whole exome sequencing data from 24 patients. The Agilent SureSelect Human All Exon 50-Mb target enrichment kit was used to capture all human exons for deep sequencing. For each patient a tumour and control sample has been sequenced on a Illumina HiSeq2000 instrument in paired-...
EGAD00001003973 | EGA
Genomicsena-DATASET-dkfz_b062-23-02-2018-16:41:10:412-192 - samples
This dataset contains ChIP sequencing data from 24 patients. ChIP of 5–10 mg flash-frozen primary ependymoma tumour was performed using 5 mg H3K27ac antibody per ChIP experiment. The enriched DNA has been sequenced on a Illumina HiSeq2000 instrument in paired-end mode. Up to two lanes per sampl...
EGAD00001003979 | EGA
Genomicsena-DATASET-dkfz_b062-16-02-2018-17:18:40:151-347 - samples
This dataset conatains RNA sequencing data from 24 patients. Up to two lanes per tumour sample have been seqeunced on a Illumina HiSeq2000 instrument in paired-end mode resulting in 58 Fastq files.
EGAD00001003966 | EGA
Genomicsena-DATASET-dkfz_b062-31-01-2018-17:04:38:652-360 - samples
This dataset contains whole genome sequencing data from 24 patients. For each patient a tumour and control sample has been sequenced on a Illumina HiSeq2000 instrument in paired-end mode. Up to three lanes per sample have been sequenced resulting in 112 Fastq files.
EGAD00001003940 | EGA
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