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ProteomicsThe Scar/WAVE complex drives normal actin protrusions without the VCA domain, but proline-rich domains are required
The Scar/WAVE regulatory complex (WRC) is the main catalyst of pseudopod and lamellipodium formation during cell migration. Its actin nucleation activity has been attributed to its ability to activate the Arp2/3 complex through the VCA domain of Scar/WAVE. Here we show in both B16-F1 mouse melanoma...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-30 | PXD037123 | Pride
Polyproline. Scar/wave Actin Wrc Arp2/3 
ProteomicsMudPIT analyses of the proteins co-purified with FLAG-HA Non-Stop FLAG-IPed from Drosophila melanogaster S2 cells
Protein Complexes Purification- Drosophila S2 cells were stably-transfected with pRmHa3-based inducible expression vectors to produce epitope-tagged Non-stop-2xFLAG-2xHA (Non-stop-FH). Cells stably transfected with empty vector served as negative control. Protein complexes containing Non-stop were p...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2018-07-17 | MSV000082625 | MassIVE
UnknownStructural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.
Not available
S-EPMC7955166 | biostudies-literature
UnknownActivation of Arp2/3 complex-dependent actin polymerization by plant proteins distantly related to Scar/WAVE.
Not available
S-EPMC528980 | biostudies-literature
UnknownAbi is required for modulation and stability but not localization or activation of the SCAR/WAVE complex.
Not available
S-EPMC3837927 | biostudies-literature
UnknownAKT and SGK kinases regulate cell migration by altering Scar/WAVE complex activation and Arp2/3 complex recruitment.
Not available
S-EPMC9466652 | biostudies-literature
UnknownLeep1 interacts with PIP3 and the Scar/WAVE complex to regulate cell migration and macropinocytosis.
Not available
S-EPMC8127007 | biostudies-literature
UnknownHomologs of SCAR/WAVE complex components are required for epidermal cell morphogenesis in rice.
Not available
S-EPMC5301933 | biostudies-literature
UnknownSCAR/WAVE complex recruitment to a supracellular actomyosin cable by myosin activators and a junctional Arf-GEF during Drosophila dorsal closure.
Not available
S-EPMC9635279 | biostudies-literature
ProteomicsFam49/CYRI interacts with Rac1 and locally suppresses protrusions
Actin-based protrusions driving cell migration are reinforced through positive feedback, but it is unclear how the cell restricts the eventual size of protrusions, or limits positive signals to allow them to split or retract. We have identified an evolutionarily conserved regulator of the protrusio...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2018-10-08 | PXD010460 | Pride
Lamellipodia Cyfip-related rac interactor Dictiostelium discoideus Gfp-trap with formaldehyde crosslinking Scar/wave complex Cell migration 
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