Scar/wave - OmicsDI

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These mice have a relatively normal first wave of spermatogenesis but never become fertile. Older animals show increased apoptosis of germ cells, increasing in severity as germ cell stage advances. (1)
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CHEBI:110 (2)

Metabolite Name

L-Cystine (3)
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[2,6-dihydroxy-3-(3,5,6,7-tetrahydroxy-4-oxo-4H-chromen-2-yl)phenyl]oxidanesulfonic acid (2)
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(-)-Quebrachamine (2)
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IsPrivate

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First Public Date

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Modelling Approach

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Release Date

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2013 (38)
2015 (33)
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Lab affiliation

CRUK - Beatson Institute for Cancer Research - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (1)
CRUK Beatson Institute, Switchback Road, Glasgow G61 1BD, UK. (1)
CRUK Scotland Institute, Garscube Estate, Switchback Road, Glasgow, G61 1BD Department of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK (1)
Centre for Craniofacial & Regenerative Biology, King’s College London/ Randall Centre for Cell & Molecular Biophysics, King’s College London (1)

Tags

xref:PubMed:36750094 (1)

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The Scar/WAVE complex drives normal actin protrusions without the VCA domain, but proline-rich domains are required

The Scar/WAVE regulatory complex (WRC) is the main catalyst of pseudopod and lamellipodium formation during cell migration. Its actin nucleation activity has been attributed to its ability to activate the Arp2/3 complex through the VCA domain of Scar/WAVE. Here we show in both B16-F1 mouse melanoma...

ORGANISM(S): Mus musculus (Mouse)

2024-08-30 | PXD037123 | Pride

MudPIT analyses of the proteins co-purified with FLAG-HA Non-Stop FLAG-IPed from Drosophila melanogaster S2 cells

Protein Complexes Purification- Drosophila S2 cells were stably-transfected with pRmHa3-based inducible expression vectors to produce epitope-tagged Non-stop-2xFLAG-2xHA (Non-stop-FH). Cells stably transfected with empty vector served as negative control. Protein complexes containing Non-stop were p...

ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227)

2018-07-17 | MSV000082625 | MassIVE

Improving peptide fragment ion detection using travelling wave ion mobility spectrometry with signal enhancement MSE (seMSE)

Recently, a solution to inherent poor ion beam sampling of time-of-flight (TOF) mass analyzers was proposed by restricting detection to ions expected at specific arrival times after being separated in a travelling wave ion mobility spectrometry (TWIMS) cell. Here, we show that this approach can be a...

ORGANISM(S): Oryctolagus Cuniculus Escherichia Coli Bos Taurus Saccharomyces Cerevisiae

PXD030431 | panorama

Transcriptomic sequencing of the murine testis during the first wave of spermatogenesis

Our experimental design includes samples at different time points during the first wave of spermatogenesis. Each time point corresponds to specific cell content in the testis. First time point is post natal day (PND) 7, when only somatic cells and spermatogonia are present in the testis. Thereafter ...

ORGANISM(S): Mus musculus

2013-04-29 | E-GEOD-39970 | biostudies-arrayexpress

Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation.

Not available

S-EPMC4961229 | biostudies-literature

Structural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.

Not available

S-EPMC7955166 | biostudies-literature

Activation of Arp2/3 complex-dependent actin polymerization by plant proteins distantly related to Scar/WAVE.

Not available

S-EPMC528980 | biostudies-literature

SCAR/WAVE is activated at mitosis and drives myosin-independent cytokinesis.