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ProteomicsSwarms of specialized fibroblasts drive scarring through N-cadherin
Injury in mammals induces a connective tissue response to either regenerate as before, or to scar. The fibroblastic actions and mechanisms that underlie these connective tissue responses remain obscure, as direct observation in animals is too difficult and current assays do not faithfully reproduce ...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-26 | PXD016068 | Pride
Live imaging Collective migration Fibroblastic swarm Cell lineage Contraction Scad Scarring Scar progenitors N-cadherin 
TranscriptomicsActivation of innate immune pathways after brain injury promotes scar formation and impairs tissue recovery
Scar formation is a major hindrance to central nervous system regeneration upon traumatic injury. Glial cells are key players during the wound healing process, and their reaction to injury determines the extent of tissue restoration. Here, we used the regenerative potential of the zebrafish telencep...
ORGANISM(S): Danio rerio 
2022-01-18 | GSE98217 | GEO
UnknownCD201<sup>+</sup> fascia progenitors choreograph injury repair.
Not available
S-EPMC10665192 | biostudies-literature
TranscriptomicsChromatin immunoprecipitation of mouse pancreatic beta-cells.
To gain insights into how pancreatic beta-cells are programmed in vivo, we profiled key histone methylations (H3K4/K27me3) in embryonic stem cells, multipotent progenitors of the nascent embryonic pancreas, purified beta-cells, and 10 other adult tissues (all under normal, untreated conditions). For...
ORGANISM(S): Mus musculus 
2010-03-19 | E-TABM-906 | biostudies-arrayexpress
TranscriptomicsFezf2 overexpression in murine cortical progenitors in vivo
Corticospinal motor neurons (CSMN) are one specialized class of cortical excitatory neurons, which connect layer Vb of the cortex to the spinal cord. a master transcription factor –Forebrain expressed zinc finger 2 (Fezf2) – has been identified that is necessary for the fate specification of CSMN. F...
ORGANISM(S): Mus musculus 
2014-07-06 | E-GEOD-56451 | biostudies-arrayexpress
UnknownMigratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors.
Not available
S-EPMC9106586 | biostudies-literature
TranscriptomicsTranscriptional profiling of mouse pancreatic beta-cells, embryonic stem cells and 10 other normal adult tissues.
To gain insights into how pancreatic beta-cells are programmed in vivo, we profiled key histone methylations (H3K4/K27me3) in embryonic stem cells, multipotent progenitors of the nascent embryonic pancreas, purified beta-cells, and 10 other adult tissues (all under normal, untreated conditions). For...
ORGANISM(S): Mus musculus 
2010-03-19 | E-TABM-877 | biostudies-arrayexpress
TranscriptomicsBrain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke
Functional revascularization is key to stroke recovery and requires remodelling of blood vessels, around which is located the brain’s only stromal compartment. Stromal progenitor cells (SPC) form a functional grouping of cells critical for tissue regeneration following injury in many organs, yet the...
ORGANISM(S): Mus musculus 
2025-02-03 | GSE146930 | GEO
GenomicsSingle-cell transcriptomics of Hic1 lineage cells recruited during regenerative and scar-forming skin wound healing.
Single-cell transcriptomics of Hic1 lineage cells recruited during regenerative and scar-forming skin wound healing.
PRJNA428247 | ENA
UnknownSox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors.
Not available
S-EPMC8105340 | biostudies-literature
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