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TranscriptomicsmiRNA expression profiling in high-risk neuroblastoma
In the present study we evaluated the miRNA expression profile of 31 high risk, stage 4 neuroblastoma patients. We compared miRNA expression profiles of 14 long-survivors (alive with an overall survival time > 36 months) and 17 short-survivors (dead of disease within 36 months from diagnosis. Deaths...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-16444 | biostudies-arrayexpress
TranscriptomicsHigh-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)
Less than 30% of children with high-risk (HR) metastatic neuroblastoma (NB) show a long survival (Pearson 2000). In order to identify novel molecular prognostic markers useful to better predict patientsM-bM-^@M-^Y relapse risk estimation, we performed genome- and/or transcriptome-wide analyses of 12...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-35953 | biostudies-arrayexpress
TranscriptomicsGenomic aberrations in distant fields from oral potentially malignant lesions by high resolution DNA flow cytometry and array-CGH
The aim of the study was to address the concept of field cancerization in oral cancer. The presence of genomic aberrations, indicative of chromosomal instability (CIN), in oral distant fields (ODFs) of visually normal and non-dysplastic mucosa at the mirror image from concomitant oral potentially ma...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28906 | biostudies-arrayexpress
TranscriptomicsStorage time does not modify the gene expression profile of cryopreserved human metaphase II oocytes
Study question: Does storage time impact on transcriptome of slowly frozen cryopreserved human metaphase II (MII) oocytes? Summary answer: For the first time, we demonstrate that the length of cryostorage has no effect on the gene expression profile of human metaphase II oocytes. What is known alrea...
ORGANISM(S): Homo sapiens 
2015-09-19 | E-GEOD-69768 | biostudies-arrayexpress
TranscriptomicsHigh-resolution, genome-wide analysis of human medulloblastoma samples by array-Comparative Genomic Hybridization (aCGH)
Medulloblastoma (MB) is the most common pediatric brain tumor and is an aggressive neoplasia arising in the cerebellum. MB includes four major histological subsets commonly subdivided in: classic, desmoplastic, anaplastic or large-cell, and nodular. The current patients risk stratification is based ...
ORGANISM(S): Homo sapiens 
2011-01-01 | E-GEOD-23005 | biostudies-arrayexpress
TranscriptomicsChromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue.
The mucosae of the oral cavity are different at the histological level but are all exposed to common genotoxic agents. As a result of this exposure, changes in the mucosal epithelia develop giving rise to Oral Potentially Malignant Lesions (OPMLs), which with time may in turn progress to Oral Squamo...
ORGANISM(S): Homo sapiens 
2011-10-19 | E-GEOD-28868 | biostudies-arrayexpress
TranscriptomicsBone marrows infiltrating human neuroblastoma cells express high levels of calprotectin and HLA-G proteins.
In neuroblastoma (NB) patients metastasis are the main cause of death, thus understanding the biological and genetic features of the metastatic NB cells is needed to reach efficient target-based therapies for high risk patients. In recent years, several prognostic signatures derived from gene expres...
ORGANISM(S): Homo sapiens 
2012-01-20 | E-GEOD-25623 | biostudies-arrayexpress
TranscriptomicsDeregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients
Presence of BM-infiltrating neuroblastoma (NB) cells occurs in about 50% of patients affected by this peculiar pediatric cancer. Children aged more than 18 months at diagnosis with metastatic NB are high-risk patients with 25-30% overall survival at 5 years, despite multimodal aggressive therapy. Li...
ORGANISM(S): Homo sapiens 
2015-04-20 | E-GEOD-65153 | biostudies-arrayexpress
TranscriptomicsHigh-resolution, genome-wide analysis of human metastatic neuroblastoma samples by array-Comparative Genomic Hybridization (aCGH)
Neuroblastoma (NB) is an aggressive tumor that affects both infants and children. The disease outcome is greatly influenced by age of patient, stage, chromosome copy number aberrations (CNAs) and gene expression abnormalities. We analyzed, by microarray technology, genome and transcriptome of 3 grou...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-25771 | biostudies-arrayexpress
TranscriptomicsThe bone marrow microenvironment in patients with neuroblastoma: presence of IFN signature and significant down-regulation of CXCL12 expression
Neuroblastoma (NB) is the most common extra cranial solid tumor in infants. Although several risk factors including patient age, disease stage and genetic abnormalities, such as MYCN amplification and 11q deletion, have been shown to predict outcome, the mechanisms responsible for the heterogeneous ...
ORGANISM(S): Homo sapiens 
2011-09-29 | E-GEOD-25624 | biostudies-arrayexpress
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