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ProteomicsPhosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 AML Cells
Constitutively activating internal tandem duplication (ITD) alterations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) are common in acute myeloid leukemia (AML) and classifies FLT3 as an attractive therapeutic target. So far, application of FLT3 small molecule inhibitors such as ...
ORGANISM(S): Homo sapiens (Human) 
2017-05-02 | PXD004442 | Pride
Phosphoproteomics Sorafenib Flt3 Acute myeloid leukemia 
ProteomicsComparative Proteomic Analysis of Eleven Common Cell Lines Reveals Ubiquitous but Varying Expression of Most Proteins
Deep proteomic analysis of mammalian cell lines would yield an inventory of the building blocks of the most commonly used systems in biological research. Mass spectrometry-based proteomics can identify and quantify proteins in a global and unbiased manner and can highlight the cellular processes tha...
ORGANISM(S): Homo sapiens (Human) 
2024-04-25 | PXD051723 | Pride
Mass spectrometry-based proteomics Silac Human Metabolic pathways 
ProteomicsGlobal phosphoproteome analysis of human bone marrow reveals predictive phosphorylation markers for the treatment of acute myeloid leukemia with quizartinib
Treatment with inhibitors of the receptor tyrosine kinase FLT3 are currently studied as promising therapies in acute myeloid leukemia (AML). However, only a subset of patients benefit from these treatments and the presence of activating mutations within FLT3 can predict response to a certain extent ...
ORGANISM(S): Homo sapiens (Human) 
2017-05-10 | PXD006475 | Pride
Biomarker  classification  aml  ac220  quizartinib  phosphoproteomics  response prediction 
ProteomicsIntegrated genomics and proteomics to define huntingtin CAG length-dependent molecular networks in HD mouse brains
To gain insight into how mutant Huntingtin (mHTT) CAG repeat length may modify Huntington’s disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat length. We find repeat length dependent transcriptional signatures ...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-16 | PXD003442 | Pride
Proteomics Striatum Huntington disease Label-free Mouse brain 
ProteomicsEleven_COM_CellLine
Comparative proteomic analysis of eleven common cell lines
ORGANISM(S): Homo Sapiens (human) 
2012-12-31 | PAe003664 | PeptideAtlas
ProteomicsProteome of Arabidopsis thaliana pux10-1 mutant lipid droplets
The analysis of proteins isolated from whole seedling homogenate allowed insight into the abundance of lipid droplet proteins in different lines and time points. In order to gain more detailed insight into the protein composition of LDs of the different mutant lines and to increase the chances for t...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2018-08-13 | PXD009248 | Pride
Arabidopsis thaliana Pux10 Lipid droplets Seedling 
ProteomicsHs_Hela_Tyr_unstimulated
HeLa S3 cells, Tyr phosphorylation, Control
ORGANISM(S): Homo Sapiens (human) 
2014-12-31 | PAe005272 | PeptideAtlas
ProteomicsUltra-deep human phosphoproteome reveals different regulatory nature of Tyr and Ser/Thr-based signaling
Regulatory protein phosphorylation controls nearly every normal and pathophysiological signaling system in eukaryotic cells. Despite great advances in mass spectrometry based-proteomics, the total number, localization and site-specific stoichiometry of this post-translational modification (PTM) are ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080701 | MassIVE
ProteomicsProteome analysis of huntingtin knock-in allelic series - Hippocampus
The objective of this project is to study the proteome in different tissues of huntingtin knock-in allelic series in mice. In the current part of the study, hippocampus samples from the complete remaining allelic series collected at 2, 6, and 10 months were analyzed. To this end, comprehensive quant...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-23 | PXD005538 | Pride
Proteomics Hippocampus Huntington's disease 
ProteomicsProteome analysis of huntingtin knock-in allelic series - Cerebellum
The objective of this project is to study the proteome in different tissues of huntingtin knock-in allelic series in mice. In the current part of the study, cerebellum samples from the complete remaining allelic series collected at 2, 6, and 10 months were analyzed. To this end, comprehensive quanti...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-23 | PXD005526 | Pride
Proteomics Cerebellum Huntington's disease 
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