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ProteomicsProteome analysis of huntingtin knock-in allelic series - Hippocampus
The objective of this project is to study the proteome in different tissues of huntingtin knock-in allelic series in mice. In the current part of the study, hippocampus samples from the complete remaining allelic series collected at 2, 6, and 10 months were analyzed. To this end, comprehensive quant...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-23 | PXD005538 | Pride
Proteomics Hippocampus Huntington's disease 
ProteomicsProteome analysis of huntingtin knock-in allelic series - Cerebellum
The objective of this project is to study the proteome in different tissues of huntingtin knock-in allelic series in mice. In the current part of the study, cerebellum samples from the complete remaining allelic series collected at 2, 6, and 10 months were analyzed. To this end, comprehensive quanti...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-23 | PXD005526 | Pride
Proteomics Cerebellum Huntington's disease 
ProteomicsProteome analysis of huntingtin knock-in allelic series - Striatum
The objective of this project is to study the proteome in different tissues of huntingtin knock-in allelic series in mice. In the current part of the study, striatum samples from the complete remaining allelic series collected at 2, 6, and 10 months were analyzed. To this end, comprehensive quantita...
ORGANISM(S): Mus musculus (Mouse) 
2017-05-26 | PXD006302 | Pride
Proteomics Striatum Huntington's disease 
ProteomicsProteome analysis of huntingtin knock-in allelic series - Liver
The objective of this project is to study the proteome in different tissues of huntingtin knock-in allelic series in mice. In the current part of the study, liver samples from the complete remaining allelic series collected at 2, 6, and 10 months were analyzed. To this end, comprehensive quantitativ...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-22 | PXD005641 | Pride
Proteomics Liver Huntington's disease 
ProteomicsPhosphoproteome Analysis Reveals Differential Mode of Action of Sorafenib in Wildtype and Mutated FLT3 AML Cells
Constitutively activating internal tandem duplication (ITD) alterations of the receptor tyrosine kinase FLT3 (Fms-like tyrosine kinase 3) are common in acute myeloid leukemia (AML) and classifies FLT3 as an attractive therapeutic target. So far, application of FLT3 small molecule inhibitors such as ...
ORGANISM(S): Homo sapiens (Human) 
2017-05-02 | PXD004442 | Pride
Phosphoproteomics Sorafenib Flt3 Acute myeloid leukemia 
ProteomicsGlobal phosphoproteome analysis of human bone marrow reveals predictive phosphorylation markers for the treatment of acute myeloid leukemia with quizartinib
Treatment with inhibitors of the receptor tyrosine kinase FLT3 are currently studied as promising therapies in acute myeloid leukemia (AML). However, only a subset of patients benefit from these treatments and the presence of activating mutations within FLT3 can predict response to a certain extent ...
ORGANISM(S): Homo sapiens (Human) 
2017-05-10 | PXD006475 | Pride
Biomarker  classification  aml  ac220  quizartinib  phosphoproteomics  response prediction 
ProteomicsIntegrated genomics and proteomics to define huntingtin CAG length-dependent molecular networks in HD mouse brains
To gain insight into how mutant Huntingtin (mHTT) CAG repeat length may modify Huntington’s disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat length. We find repeat length dependent transcriptional signatures ...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-16 | PXD003442 | Pride
Proteomics Striatum Huntington disease Label-free Mouse brain 
ProteomicsProteome analysis of huntingtin knock-in allelic series - Heart
The objective of this project is to study the proteome in different tissues of huntingtin knock-in allelic series in mice. In the current part of the study, heart samples from the complete allelic series collected at 2, 6, and 10 months were analyzed. To this end, comprehensive quantitative, label-f...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-03 | PXD010958 | Pride
Phosphoproteomics Mouse Heart Huntington's disease 
ProteomicsProteome analysis of huntingtin knock-in allelic series - Muscle
The objective of this project is to study the proteome in different tissues of huntingtin knock-in allelic series in mice. In the current part of the study, gastrocnemius samples from the complete remaining allelic series collected at 2, 6, and 10 months were analyzed. To this end, comprehensive qua...
ORGANISM(S): Mus musculus (Mouse) 
2018-09-03 | PXD010957 | Pride
Phosphoproteomics Gastrocnemius Mouse Huntington's disease 
ProteomicsPhosphoproteome and Proteome Time Series Analysis of R6/2 and WT Mice Striatum
Animal models play a critical role in the study of Huntington’s disease (HD), for example to elucidate underlying molecular mechanisms or to develop novel therapeutic venues. One of the first transgenic mouse models of HD, the R6/2 line, has been described in 1996 and has since become one of the mos...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-03 | PXD013771 | Pride
Huntington's disease  phosphoproteome  proteome  r6/2  striatum 
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