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TranscriptomicsDetermination of the transcription start sites of heterologous promoters in Actinoplanes sp. SE50/110 by 5'-end specific transcriptome sequencing
The promoter structure influences binding and clearance of RNA polymerase and therefore substantially influences expression of a gene. A promoter usually consists of a -10 and a -35-region, an extended -10-motif and A+T-rich upstream promoter elements. Most of these elements are optional, whereas th...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-26 | E-MTAB-8433 | biostudies-arrayexpress
UnknownEssentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in the Acarbose-Producing Bacterium Actinoplanes sp. SE50/110.
Not available
S-EPMC6828939 | biostudies-literature
TranscriptomicsComplex response on the level of the transcriptome by deletion of a local transcriptional repressor AmlR by RNAseq of the coding RNA
Actinoplanes sp. SE50/110 is the wild type of industrial production strains of the fine-chemical acarbose (acarviosyl-maltose), which is used as α-glucosidase inhibitor in the treatment of type II diabetes. Although maltose is an important building block of acarbose, the maltose/maltodextrin metabol...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-07 | E-MTAB-8404 | biostudies-arrayexpress
ProteomicsAdverse Effects of Bisphenol A and its substitute compounds on human SGBS preadipocytes
Bisphenol A (BPA), which is used in a variety of consumer-related plastic products, was reported to cause metabolic disruption. Substitute compounds are increasingly emerging, but are not sufficiently investigated. In this study, we aimed to investigate the mode of action of BPA and four of its subs...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD023227 | Pride
Bpa Adipocytes Sgbs Human Bisphenol a 
TranscriptomicsWhole track RNAseq of the deletion mutant delta cgt in Actinoplanes sp. SE50/110 during growth phase and during transition into stationary phase
Actinoplanes sp. SE50/110 (ATCC 31044) is the wild type of industrial producer strains of acarbose. Acarbose is used since the early 1990s as an inhibitor of intestinal human alpha-glucosidases in the medical treatment of type II diabetes mellitus. The small secreted protein Cgt, which consists of a...
ORGANISM(S): Actinoplanes sp. SE50/110 
2020-09-01 | E-MTAB-8432 | biostudies-arrayexpress
TranscriptomicsWhole track RNAseq of two vector integration mutants of Actinoplanes sp. SE50/110 (pSET152::acbB and pSETT4::acbB).
The whole coding RNA of Actinoplanes sp. SE50/110 mutants containing two different integrative vectors (pSET152::acbB and pSETT4::acbB) were sequenced. Both vectors are integrated via a phiC31 integrase (Bierman et al. 1992) into the genetic locus ACSP50_6589 (former: acpl_6602) (Gren et al. 2016). ...
ORGANISM(S): Actinoplanes sp. SE50/110 
2020-05-30 | E-MTAB-8967 | biostudies-arrayexpress
TranscriptomicsWhole track RNAseq of two different integrative vectors: pSET152::PrpsJ:acbC and pGUS::PrpsJ:gusA. in Actinoplanes sp. SE50/110.
The whole coding RNA of Actinoplanes sp. SE50/110 mutants containing two different integrative vectors (pSET152::PrpsJ:acbC and pGUS::PrpsJ:gusA) were sequenced. Both vectors are integrated via a phiC31 integrase (Bierman et al. 1992) into the genetic locus ACSP50_6589 (former: acpl_6602) (Gren et a...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-15 | E-MTAB-8431 | biostudies-arrayexpress
UnknownThe genetic architecture of phosphorus efficiency in sorghum involves pleiotropic QTL for root morphology and grain yield under low phosphorus availability in the soil.
Not available
S-EPMC6394046 | biostudies-literature
UnknownIL-12 enhances efficacy and shortens enrichment time in cytokine-induced killer cell immunotherapy.
Not available
S-EPMC4922493 | biostudies-literature
UnknownCMV-Responsive CD4 T Cells Have a Stable Cytotoxic Phenotype Over the First Year Post-Transplant in Patients Without Evidence of CMV Viremia.
Not available
S-EPMC9275561 | biostudies-literature
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