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ProteomicsThe esterase PfeE, Achilles heel in the battle for iron between Pseudomonas aeruginosa and Escherichia coli
Bacteria access iron, a key nutrient, by producing siderophores or using siderophores produced by other microorganisms. The pathogen Pseudomonas aeruginosa produces two siderophores but is also able to pirate enterobactin (ENT), the siderophore produced by Escherichia coli. ENT-Fe complexes are impo...
ORGANISM(S): Pseudomonas aeruginosa PAO1 Escherichia coli 
2021-04-29 | PXD023712 | Pride
Pseudomonas Pfee Siderophore Co-culture Iron 
ProteomicsA role for PchHI as an ABC transporter in iron acquisition by the siderophore pyochelin in Pseudomonas aeruginosa
Iron is an essential nutrient for bacterial growth but poorly bioavailable. To scavenge ferric iron present in their environment, bacteria synthesize and secrete siderophores, small compounds with a high affinity for iron. Pyochelin (PCH) is one of the two siderophores produced by the opportunistic ...
ORGANISM(S): Pseudomonas aeruginosa 
2022-03-15 | PXD026833 | Pride
Pseudomonas Pchhi Iron Siderophore Pyochelin 
ProteomicsHow the presence of hemin affects the expression of all iron-uptake pathways in Pseudomonas aeruginosa cells
Iron is an essential nutriment for almost all organisms, but this metal is poorly bioavailable. During infection, bacteria access iron from the host by importing either iron or hemin. Pseudomonas aeruginosa, a Gram-negative pathogen, secretes two siderophores, pyoverdine (PVD) and pyochelin (PCH), t...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2022-03-15 | PXD028818 | Pride
Pseudomonas Hemin Iron uptake pathway 
ProteomicsUptake mechanisms and regulatory responses to MECAM- and DOTAM-based artificial siderophores and their antibiotic conjugates in Pseudomonas aeruginosa
The development of new antibiotics against Gram-negative bacteria has to deal with the low permeability of the outer membrane. This obstacle can be overcome by utilizing siderophore-dependent iron uptake pathways as gates for antibiotic uptake. Iron-chelating siderophores are actively imported by ba...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2022-10-28 | PXD031065 | Pride
Antibiotic conjugate Pseudomnas Dotam Siderophore Mecam 
ProteomicsSiderophore specifities of ChtA and ActA, two TonB-dependent transporters of Pseudomonas
Iron is an essential nutrient for the opportunistic pathogen Pseudomonas aeruginosa, as for almost all living organisms. To access this element, the pathogen is able to express at least 15 different iron-uptake pathways, the vast majority involving small iron chelators called siderophores. Indeed, P...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2023-09-21 | PXD043056 | Pride
Pseudomonas Chta Acta Siderophore 
ProteomicsNocardamine-dependent iron uptake in Pseudomonas aeruginosa : exclusive implication of the FoxA outer membrane transporter
Iron is a key nutrient for almost all living organisms and paradoxically poorly soluble and consequently poorly bioavailable. To get access to this metal, bacteria have developed many different strategies. One of the most common consists of the use of siderophores, small compounds chelating ferric i...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2021-04-29 | PXD020868 | Pride
Foxa Iron uptake Pseudomonas Nocardamine 
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