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MetabolomicsClostridium bolteae suppresses Enterobacteriaceae expansion and restores gut microbiome homeostasis via disrupting siderophore-mediated iron acquisition

Intestinal inflammation and the related gut microbiome dysbiosis are becoming prevalent worldwide. Overgrowth of Enterobacteriaceae exacerbates intestinal inflammation and gut microbiome dysbiosis. Enterobacteriaceae secrets siderophore to acquire iron and survive in the iron-limited gut. Therefo...

2026-01-03 | MTBLS13592 | MetaboLights
TranscriptomicsGene expression profiling of siderophore-drug resistant mutant of Pseudomonas aeruginosa PAO1
The aim of the experiment was to identify genes differentially expressed between the susceptible wild type strain P. aeruginosa PAO1 (PT5) and a mutant resistant to a drug-siderophore conjugate, in order to obtain information on the resistance mechanism(s). A mutant of PT5 able to grow at 4 mg/l BA...
ORGANISM(S): Pseudomonas aeruginosa 
2013-04-17 | E-MTAB-1381 | biostudies-arrayexpress
TranscriptomicsFunctional redundancy of iron acquisition systems is required for Proteus mirabilis pathogenesis during UTI
Proteus mirabilis is a primary cause of complicated urinary tract infections (UTI). Surprisingly, iron acquisition systems have been poorly characterized in this uropathogen despite the urinary tract being iron-limited. In this report the transcriptome of strain HI4320, cultured under iron limitat...
ORGANISM(S): Proteus mirabilis HI4320 
2010-09-09 | E-GEOD-18051 | biostudies-arrayexpress
ProteomicsFrench et al, P. biseptata siderophore degradation, 2023
LC-MS/MS analysis of P. biseptata supernatant samples after incubation with DFOB and protochelin
ORGANISM(S): Pyrenophora Biseptata (ncbitaxon:2211333) 
MSV000092898 | MassIVE
ProteomicsA role for PchHI as an ABC transporter in iron acquisition by the siderophore pyochelin in Pseudomonas aeruginosa
Iron is an essential nutrient for bacterial growth but poorly bioavailable. To scavenge ferric iron present in their environment, bacteria synthesize and secrete siderophores, small compounds with a high affinity for iron. Pyochelin (PCH) is one of the two siderophores produced by the opportunistic ...
ORGANISM(S): Pseudomonas aeruginosa 
2022-03-15 | PXD026833 | Pride
Pseudomonas Pchhi Iron Siderophore Pyochelin 
TranscriptomicsDifferential expression of genes in the WT and hupB KO strain of Mycobacterium tuberculosis H37Rv upon iron limitation
HupB is a 28 kDa in Mycobacterium tuberculosis that is co-expressed with the siderophores mycobactin and carboxymycobactin upon iron limitation. High levels of all the three components are seen in low iron (LI; 0.02 M-BM-5g Fe / mL) organisms, with negligible expression in high iron organisms (HI; 8...
ORGANISM(S): Mycobacterium tuberculosis 
2014-03-18 | E-GEOD-53254 | biostudies-arrayexpress
ProteomicsTiO2 Nanoparticle for Siderophore Extraction
Novel and more efficient technique for selectively enriching siderophore from complex microbiome
ORGANISM(S): Pseudomonas 
2024-07-30 | MSV000095484 | MassIVE
GenomicsRGS4 impacts carbohydrate and siderophore metabolism in Trichoderma reesei
RGS4 impacts carbohydrate and siderophore metabolism in Trichoderma reesei
PRJNA896230 | ENA
ProteomicsThe proteomic response of a marine Vibrio to low iron and desferrioxamine siderophore bioavailability
Competition for limited iron resources is a key driver of microbial community structure in many regions of the surface ocean. The bacterial siderophores ferrioxamine and amphibactin have been identified in marine surface waters, suggesting that they may represent an important bacterial strategy for ...
ORGANISM(S): Vibrio cyclitrophicus 1F53 
2021-04-19 | PXD011427 | Pride
Iron bioavailability Thermo fusion q-exactive Ferrioxamine Siderophore 
ProteomicsPhenotypical adaptation of Pseudomonas aeruginosa in the presence of siderophore-antibiotic conjugates during epithelial cell infection
This study aims at investigating the ability of Pseudomonas aeruginosa to detect the presence of siderophore-antibiotic conjugates in an epithelial cell infection assay. We show that the presence of siderophore-antibiotic conjugates induces the transcription and expression of their corresponding tra...
ORGANISM(S): Homo sapiens (Human) Pseudomonas aeruginosa PAO1 
2021-02-18 | PXD020378 | Pride
Sideromycin Trojan horse antibiotic Pseudomonas aeruginosa Siderophore Nanolc-ms/ms Label-free analysis. 
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