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ProteomicsReduced collagen degradation in pelvic urine precedes kidney fibrosis induced by unilateral ureteral obstruction
Kidney fibrosis is a major hallmark of chronic kidney disease and is defined by an excessive accumulation of extracellular matrix, primarily collagens. While collagen synthesis has been extensively investigated, the contribution of impaired collagen degradation to the development of fibrosis remains...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD064569 | Pride
Chronic kidney disease Kidney fibrosis Urine Unilateral ureteral obstruction Ce-ms/ms 
ProteomicsDevelopment of a capillary electrophoresis coupled to mass spectrometry pipeline for comparable assessment of the plasma peptidome
Although capillary electrophoresis coupled to mass spectrometry (CE-MS) holds promise for urinary peptide profiling, only a limited number of studies have used CE-MS to study plasma peptides. Here we describe the establishment of a workflow, including sample preparation, CE-MS and MS/MS analyses, da...
ORGANISM(S): Homo sapiens (Human) 
2025-05-16 | PXD056224 | Pride
Chronic kidney disease Plasma Cardiovascular diseases Peptidome Biomarkers Ce-ms/ms 
ProteomicsConnectivity mapping of glomerular proteins identifies dimethylaminoparthenolide as a new inhibitor of diabetic kidney disease
While blocking the renin angiotensin aldosterone system (RAAS) has been the main therapeutic strategy to control diabetic kidney disease (DKD) for many years, 25-30% of diabetic patients still develop the disease. In the present work we adopted a system biology strategy to analyze glomerular protein...
ORGANISM(S): Mus musculus (Mouse) 
2020-09-17 | PXD018728 | Pride
Quantitative proteomics Nephropathy Diabetic kidney disease 
ProteomicsNano-LC-MS/MS proteomics in amniotic fluid from CAKUT patients
The objective of the present work was to identify new renal proteins responsible for Congenital Anomalies of the Kidney and of the Urinary Tract (CAKUT pathophysiology). We conducted a comparative LC-MS/MS-based proteomics analysis of amniotic fluids (AF) collected from non-severe CAKUT (ns-CAKUT; ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-26 | PXD022926 | Pride
Chronic kidney disease Cakut Proteomics Plastin-3 Amniotic fluid 
UnknownAssociations of urinary polymeric immunoglobulin receptor peptides in the context of cardio-renal syndrome.
Not available
S-EPMC7237418 | biostudies-literature
UnknownEvaluation of predictive performance of fetal urinary inflammatory markers of postnatal kidney function in fetuses with posterior urethral valves.
Not available
S-EPMC11885327 | biostudies-literature
UnknownComparison of the amniotic fluid and fetal urine peptidome for biomarker discovery in renal developmental disease.
Not available
S-EPMC7729974 | biostudies-literature
ProteomicsLC-MS/MS based proteomics analysis of decellularized and non-decellularized mouse kidney tissue samples
Two C57Bl6/J male mice were sacrificed by injecting 200 microliters of the lethal anaesthetic Dolethal. Kidneys were perfused with Dulbeccos Phosphate Buffered Saline, dissected, decapsulated and weighted. Kidneys were decellularized using 3 freeze-thaw cycles (freezing at -80C, 30 minute long thawi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-07 | MSV000094031 | MassIVE
UnknownSpecific macrophage subtypes influence the progression of rhabdomyolysis-induced kidney injury.
Not available
S-EPMC4446873 | biostudies-literature
UnknownConnectivity mapping of glomerular proteins identifies dimethylaminoparthenolide as a new inhibitor of diabetic kidney disease.
Not available
S-EPMC7484761 | biostudies-literature
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