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ProteomicsMHCquant2 refines immunopeptidomics tumor antigen discovery
The identification of human leukocyte antigen (HLA)-presented peptides as targets of anti-cancer T cell response is pivotal for the development of novel immunotherapies. Mass spectrometry (MS)-based immunopeptidomics enables the detection of these peptides, yet confident identifications and thus imp...
ORGANISM(S): Homo sapiens (Human) 
2025-08-22 | PXD058436 | Pride
Immunopeptidomics Nf-core Mhcquant Pipeline Dda 
ProteomicsMapping naturally presented T-cell antigens in medulloblastoma based on integrative multi-omics
Medulloblastoma is the most frequent malignant primary brain tumor in children. Despite recent advances in integrated genomics, the prognosis in children with high-risk medulloblastoma remains devastating, and new tumor-specific therapeutic approaches are needed. Here, we present an atlas of natural...
ORGANISM(S): Homo sapiens (Human) 
2024-08-24 | PXD043770 | Pride
Medulloblastoma Immunopeptidomics Rna-seq 
ProteomicsThe Immunopeptidomic Landscape of Ependymomas provide actionable antigens for T cell-based immunotherapy
Ependymoma (EPN) are primary tumors of the nervous system. Due to their growth pattern, most ependymoma can be managed with neurosurgical resection alone. A substantial proportion of these tumors recurs or display infiltrative growth pattern, however. Therapeutic options after neurosurgical resectio...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD052448 | Pride
Peptide vaccine Hla ligands Mass spectrometry Cancer vaccination Neuroepithelial tumor Immunotherapy 
UnknownDirect observation of the dead-cone effect in quantum chromodynamics.
Not available
S-EPMC9117140 | biostudies-literature
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