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ProteomicsMHCquant: Automated and reproducible data analysis for immunopeptidomics
Personalized multi-peptide vaccines are currently being discussed intensively for tumor immunotherapy. In order to find epitopes - short, immunogenic peptides - suitable to elicit an immune response, human leukocyte antigen-presented peptides from cancer tissue samples are purified using immunoaffin...
ORGANISM(S): Homo sapiens (Human) 
2019-10-14 | PXD011628 | Pride
Human Mhc Benchmark 
ProteomicsMHCquant: Automated and reproducible data analysis for immunopeptidomics
Personalized multi-peptide vaccines are currently being discussed intensively for tumor immunotherapy. In order to find epitopes - short, immunogenic peptides - suitable to elicit an immune response, human leukocyte antigen-presented peptides from cancer tissue samples are purified using immunoaffin...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-27 | MSV000098352 | MassIVE
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
A use case of the benign HLA-Ligand-Atlas is the prioritization of tumor-associated targets for e.g. peptide vaccination. Based on three glioblastoma samples, we illustrated how many of these peptides are covered in the benign dataset. The experimental and computational workflow for the isolation an...
ORGANISM(S): Homo sapiens (Human) 
2021-04-16 | PXD020186 | Pride
Human Hla Glioblastoma Immunopeptidomics 
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo sapiens (Human) 
2021-04-16 | PXD019643 | Pride
Human Hla Benign tissues Immunopeptidomics 
ProteomicsThe immunopeptidome of HLA-DR from PBMC
Quantifiying the impact of initial cell counts on the identified HLA-DR immunopeptidome of PBMC.
ORGANISM(S): Homo sapiens (Human) 
2021-08-23 | PXD023032 | Pride
Pbmc Hla-ii Immunopeptidome Human blood Hla-dr 
ProteomicsPCI-DB: A novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy development
Various cancer immunotherapies rely on the T cell recognition of peptide antigens presented on human leukocyte antigens (HLA). However, the identification and selection of naturally presented peptide targets for the development of personalized as well as off-the-shelf immunotherapy approaches remain...
ORGANISM(S): Homo sapiens (Human) 
2025-04-04 | PXD058376 | Pride
Human Lc-msms Synthetic peptides 
ProteomicsImmunopeptidomics DIA and DDA Dynamic Range Experiment
The peptide identification sensitivity of the affinity purified immunopeptidome of a JY cell line (Epstein–Barr virus-immortalized B cell lymphoblastoid line, ECACC 94022533, IHW9287) for DDA and DIA experiments was assessed by a linear concentration series. JY cells are homozygous for all HLA-I loc...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD024809 | Pride
Dynamic range Dia Immunopeptidomics Hla 
ProteomicsMHCquant2 refines immunopeptidomics tumor antigen discovery
The identification of human leukocyte antigen (HLA)-presented peptides as targets of anti-cancer T cell response is pivotal for the development of novel immunotherapies. Mass spectrometry (MS)-based immunopeptidomics enables the detection of these peptides, yet confident identifications and thus imp...
ORGANISM(S): Homo sapiens (Human) 
2025-08-22 | PXD058436 | Pride
Immunopeptidomics Nf-core Mhcquant Pipeline Dda 
ProteomicsBenchmarking Software for DDA-PASEF Immunopeptidomics
Mass spectrometry (MS) is the method of choice for high-throughput identification of immunopeptides, which are generated by intracellular proteases, unlike proteomics peptides that are typically derived from trypsin-digested proteins. This distinction necessitates searching without the constraints o...
ORGANISM(S): Homo Sapiens (human) 
2026-06-26 | PXD065501 | JPOST Repository
GenomicsBenchmarking Software for DDA-PASEF Immunopeptidomics
Benchmarking Software for DDA-PASEF Immunopeptidomics
PRJEB98909 | ENA
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