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ProteomicsIdentification of inhibitors for the trans-membrane Trypanosoma cruzi eIF2alpha kinase relevant for parasite proliferation
We studied the impact of the gene knockout of the TcK2 protein kinase of Trypanosoma cruzi, the causative agent of Chagas disease. TcK2 is structurally similar to the human kinase PERK, which phosphorylates the initiation factor eIF2alpha, and in turn, inhibits translation initiation. As TcK2 kinase...
ORGANISM(S): Trypanosoma cruzi 
2023-07-20 | PXD040597 | Pride
Chemical inhibitor Recombinant protein T. cruzi eif2ak2 Protein kinase Chagas disease Invasion Proteome Assay eif2alpha 
ProteomicsProteome changes upon modulation of eIF2α phosphorylation in Trypanosoma cruzi epimastigotes
Trypanosomatids regulate gene expression mainly at the post-transcriptional level through processing, exporting and stabilizing mRNA and control of translation. In most eukaryotes, protein synthesis is regulated by phosphorylation of eukaryotic initiation factor 2 (eIF2) at serine 51. Phosphorylatio...
ORGANISM(S): Trypanosoma cruzi 
2020-07-06 | PXD018761 | Pride
Eif2 Virulence Differentiation Phosphorylation Trypanosoma cruzi Translation 
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