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ProteomicsStructural determinants of specificity and antagonistic Ca2+ and Zn2+ regulation of peptidase activity in human KLK8/neuropsin
Human KLK8/neuropsin, a kallikrein-related serine peptidase, is mostly expressed in skin and hippocampus, where it regulates memory formation by synaptic remodeling. Recombinantly expressed KLK8 revealed a good accordance two substrate profiling methods: positional scanning with fluorogenic tetrapep...
ORGANISM(S): Escherichia coli 
2018-10-17 | PXD006884 | Pride
Protease Peptide library 
ProteomicsProteomic Distinction of Renal Oncocytomas and Eosinophilic Chromophobe Renal Cell Carcinomas
Background Renal oncocytomas (ROs) are benign epithelial tumors of the kidney that may progress into malignant chromophobe renal cell carcinoma (chRCCs), with the latter constituting 5 – 7 % of renal neoplasias. ROs and chRCCs show pronounced molecular and histological similarities, which renders th...
ORGANISM(S): Homo sapiens (Human) 
2018-08-13 | PXD009300 | Pride
Paraffin embedment proteomics immunohistochemistry Renal cell tumors formalin-fixation 
ProteomicsA human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
The human genome consists of considerable portions derived from retroviruses typically inherited already for millions of years. So-called human endogenous retroviruses (HERVs) are usually severely mutated, yet some coding-competent HERV sequences exist. The HERV-K(HML-2) group includes evolutionaril...
ORGANISM(S): Homo sapiens (Human) 
2019-09-02 | PXD010159 | Pride
Protease N-terminomics 
ProteomicsThe bacterial porin OmpA is an inhibitor of Bak-activation at mitochondria and blocks apoptosis of human cells infected with Chlamydia trachomatis
Many infectious agents have the need to inhibit host apoptosis, and various strategies are known. Chlamydia trachomatis is an obligate intracellular bacterium replicating in a vacuole in the human cytosol. Chlamydia-infected human cells are strongly protected against apoptosis. We here mapped this a...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD011848 | Pride
Ompa Mitochondria Chlamydia trachomatis Apoptosis Bcl-2 
ProteomicsHIF-1α and HIF-2α differently regulate tumour development, metabolism and inflammation of clear cell renal cell carcinoma in mice
Mutational inactivation of VHL is the earliest genetic event in the majority of ccRCCs, leading to activation of the HIF-1α and HIF-2α transcription factors. While correlative studies of human ccRCCs and functional studies using human ccRCC cell lines have implicated HIF-1α as an inhibitor and HIF-2...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-02 | PXD016630 | Pride
Mouse model Hypoxia induced factor Renal cancer 
ProteomicsProteome Profiling of Renal Cancer Tumor Tissue and Non-Affected Renal Tissue in Patients with Von Hippel-Lindau Disease Highlights Differential Regulation of Xaa-Pro Aminopeptidases-1 and -2 (XPNPEP-1 and -2)
Patients with loss-of-function mutations of the von Hippel Lindau gene (“VHL-patients”) often develop clear cell renal cell carcinoma (ccRCC). Using archived, formalin-fixed, paraffin-embedded (FFPE) samples and a cohort of eight cases, we sought to determine global proteome alterations that disting...
ORGANISM(S): Homo sapiens (Human) 
2017-08-28 | PXD005710 | Pride
Von-hippel-lindau Exoproteases 
ProteomicsA human endogenous retrovirus encoded protease potentially cleaves numerous cellular proteins
Background: The human genome consists of considerable portions derived from retroviruses inherited for millions of years. So-called human endogenous retroviruses (HERVs) are usually severely mutated, yet some coding-competent HERVs exist. The HERV-K(HML-2) group includes evolutionarily young proviru...
ORGANISM(S): Homo sapiens (Human) 
2019-09-02 | PXD013296 | Pride
Proteolysis Retrovirus 
ProteomicsImpact of cathepsin A on the murine cardiac proteome
Cathepsin A (CTSA) is a lysosomal carboxypeptidase present at the cell surface and secreted outside the cell. Additionally, CTSA binds to β-galactosidase and neuraminidase 1 to protect them from degradation. CTSA has gained attention as a drug target for the treatment of cardiac hypertrophy and hear...
ORGANISM(S): Mus musculus (Mouse) 
2016-07-25 | PXD003860 | Pride
Transgenic mouse Cathepsin a Lc-ms/ms 
ProteomicsFactor Xa PICS with chymotryptic peptide library
Factor Xa PICS with chymotryptic peptide library
ORGANISM(S): Homo sapiens (Human) 
2011-10-14 | PRD000421 | Pride
ProteomicsDepletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death
Background: Lung cancer is the leading cause of cancer related death worldwide. Over the past 15 years no major improvement of survival rates could be accomplished. The recently discovered histone methyltransferase KMT9 as epigenetic regulator of prostate tumor growth has now raised hopes of enablin...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD014145 | Pride
Kmt9 Non-small cell lung cancer Proteomics Epigenetics Histone methyltransferase Lung cancer A549 Transcriptomics 
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