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ProteomicsTear Fluid Proteomics: A Comparative Study of DIA and DDA Mass Spectrometry
Background: Mass spectrometry is a powerful technique for tear fluid proteomics, offering critical insights into its complex molecular composition. Data-dependent acquisition (DDA), the most commonly used approach, preferentially selects high-abundance proteins, limiting reproducibility and the quan...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-10-20 | PXD062422 | Pride
Tear fluid  schirmer strip  proteomics  biomarkers  mass spectrometry 
ProteomicsTear Fluid Proteomics: A Comparative Study of DIA and DDA Mass Spectrometry
Background: Mass spectrometry is a powerful technique for tear fluid proteomics, offering critical insights into its complex molecular composition. Data-dependent acquisition (DDA), the most commonly used approach, preferentially selects high-abundance proteins, limiting reproducibility and the quan...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2025-10-20 | PXD062423 | Pride
Tear fluid  schirmer strip  proteomics  biomarkers  mass spectrometry 
ProteomicsPrecision in Tear Fluid Biomarker Discovery: Quantitative Proteomic Profiling of Small-Volume, Individual Samples Using Capillary Tube Collection
Tear fluid, a complex biofluid that contains thousands of proteins and can be collected non-invasively, has emerged as a promising source of biomarkers for ocular and systemic health. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is currently the primary method for discovering novel biom...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060101 | Pride
1. tear proteomics  2. tear biomarker  3. biomarker discovery  4. capillary collection  5. lc-ms/ms 
ProteomicsProteomic Analysis of Tear Fluid from the Offspring of Keratoconus Patients Toward Novel Biomarkers and Pathways Associated with Corneal Biomechanical Weakness and Disease Susceptibility.
Keratoconus (KC) is a chronic and degenerative condition marked by pathological weakening, thinning, and protrusion of the corneal tissue. Corneal biomechanical weakness constitutes a hallmark of early keratoconus (KC) stages, which has underlined the importance of the study of biomechanical respons...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD049296 | Pride
Offspring Keratoconus Biomarkers Proteomics Tear fluid 
UnknownMicrobial genes and pathways in inflammatory bowel disease.
Not available
S-EPMC6759048 | biostudies-literature
MetabolomicsIntegration of metabolomics, genomics and immune phenotypes reveals the causal roles of metabolites in disease

BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.

RESULT: We systematically investigate circulating metabolites in a cohort of 5...

2021-06-14 | MTBLS2633 | MetaboLights
UnknownPopulation structure discovery in meta-analyzed microbial communities and inflammatory bowel disease using MMUPHin.
Not available
S-EPMC9531436 | biostudies-literature
UnknownSafety of Lifitegrast Ophthalmic Solution 5.0% in Patients With Dry Eye Disease: A 1-Year, Multicenter, Randomized, Placebo-Controlled Study.
Not available
S-EPMC4859202 | biostudies-literature
UnknownTerminal olefin (1-alkene) biosynthesis by a novel p450 fatty acid decarboxylase from Jeotgalicoccus species.
Not available
S-EPMC3067255 | biostudies-literature
UnknownPhyloPythiaS+: a self-training method for the rapid reconstruction of low-ranking taxonomic bins from metagenomes.
Not available
S-EPMC4748697 | biostudies-literature
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