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ProteomicsMenstrual fluid-derived extracellular vesicles as a non-invasive diagnostic tool for endometriosis
Introduction: Endometriosis is a debilitating condition where endometrial-like tissue grows outside the uterus and rarely in distant sites such as the lungs, heart and brain. Symptoms are severe chronic pain, bladder/bowel problems, painful sex and infertility. Differences in endometrium between wom...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042101 | Pride
Endometriosis Extracellular vesicles Non-invasive diagnosis Menstrual fluid 
ProteomicsSuppression of the nucleic acid precursor ribose 5-phosphate by RNA-mediated antiviral immunity.
We identify that the antiviral protein kinase PKR alters glycolysis. This response is found to be independent of the kinase’s established control of gene expression that is executed through phosphorylation of the Eukaryotic Translation Initiation Factor 2. Instead, a novel substrate is recognised wi...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD036779 | Pride
Metabolism Protein kinase r pkr Ribose 5-phosphate isomerase Antiviral immunity 
ProteomicsAn integrated multi-omic network analysis identifies seizure-associated dysregulated pathways in the GAERS model of absence epilepsy
Absence epilepsy syndromes are part of the genetic generalized epilepsies, the pathogenesis of which remains poorly understood, although a polygenic architecture is presumed. Current focus on single molecule or gene identification to elucidate epileptogenic drivers is unable to fully cap-ture the co...
ORGANISM(S): Rattus rattus (Black rat) 
2022-08-11 | PXD033987 | Pride
An integrated multi-omic network analysis identifies sei-zure-associated dysregulated pathways in the gaers model of absence epilepsy 
ProteomicsA Data-Independent-Acquisition-based proteomic approach towards understanding the acclimation strategy of Microchloropsis gaditana CCMP526 in hypersaline conditions
Salinity is one of the significant factors that affect growth and cellular metabolism, including photosynthesis and lipid accumulation, in microalgae and higher plants. Microchloropsis gaditana CCMP526 can acclimatize to different salinity levels by accumulating compatible solutes, carbohydrates, ...
ORGANISM(S): Nannochloropsis gaditana CCMP526 
2021-11-03 | PXD017297 | Pride
Proteomics Salinity Stress response Microalgae 
ProteomicsA Data-Independent-Acquisition-based proteomic approach towards understanding the acclimation strategy of Microchloropsis gaditana CCMP526 in hypersaline conditions
Salinity is one of the significant factors that affect growth and cellular metabolism, including photosynthesis and lipid accumulation, in microalgae and higher plants. Microchloropsis gaditana CCMP526 can acclimatize to different salinity levels by accumulating compatible solutes, carbohydrates, ...
ORGANISM(S): Nannochloropsis gaditana CCMP526 
2021-11-03 | PXD017164 | Pride
Proteomics Salinity Stress response Microalgae 
ProteomicsIdentification of Acinetobacter baumannii AB307-0294 type VI secretion system secreted proteins
In order to identify secreted proteins associated with the type VI secretion system (T6SS), the secretome of a wild-type A. baumannii AB307 0294 T6SS active strain was compared to the secretome of a T6SS inactive mutant strain, A. baumannii AB307-0294ΔtssM.
ORGANISM(S): Acinetobacter baumannii 
2018-05-25 | PXD009528 | Pride
Acinetobacter baumannii Tssm Type vi secretion system Bacteria Secretome 
ProteomicsTermination of STING responses is mediated via ESCRT-dependent degradation
The cGAS-STING pathway forms a major component of the innate immune system. cGAS-STING signalling is induced by detection of either foreign (i.e. pathogenic) or mislocalised host double stranded (ds)DNA present within the cytosol. STING acts as the major signalling hub, where it controls activation ...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD037108 | Pride
Cgas-sting/escrt/innate immunity/lysosomal degradation/vesicular trafficking 
ProteomicsThe role of the sRNA GcvB in Pasteurella multocida protein production
In this study, transcriptomic analysis of the P. multocida strain VP161 revealed a putative sRNA with high identity to GcvB from Escherichia coli and Salmonella enterica serovar Typhimurium. High-throughput quantitative liquid proteomics was used to compare the proteomes of the P. multocida VP161 wi...
ORGANISM(S): Pasteurella multocida 
2019-11-12 | PXD007719 | Pride
Lc-ms/ms Pasteurella multocida Gcvb 
ProteomicsThe pseudokinase NRBP1 activates Rac/Cdc42 via P-Rex1 to drive oncogenic signalling in triple negative breast cancer
In an effort to identify oncogenic protein kinase drivers in triple negative breast cancer (TNBC), we undertook mass spectrometry (MS)-based proteomic profiling across a large panel of TNBC cell lines. This revealed marked variation in expression of the multidomain pseudokinase Nuclear Receptor Bind...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD032168 | Pride
G proteins Proteomics Signal transduction Scaffold proteins 
ProteomicsProteomics reveals a fibre-type specific mitochondrial remodelling with moderate- but not very high-intensity training
Methods for studying mitochondrial adaptations in skeletal muscle have mostly used whole-muscle samples, where results may be confounded by the presence of a mixture of type I and II skeletal muscle fibres. In this project, we utilised the latest Mass spectrometry (MS) techniques to provide new insi...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD036010 | Pride
Exercise Proteomics Training Single fibre Fibre type 
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