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MetabolomicsUntargeted 1 H NMR-based metabolomics unveils distinct circulating biochemical signatures between treatment-resistant and non-treatment-resistant Schizophrenia patients: a pilot study

Schizophrenia is a severe psychiatric disorder impacting roughly 1% of individuals. The effectiveness of antipsychotic therapy greatly varies, with around 30% of patients categorised as treatment-resistant (TRS). TRS is characterised by a lack of response to at least two clinical trials invo...

2025-10-01 | MTBLS12709 | MetaboLights
TranscriptomicsTranscriptomic profiles of skin fibroblasts from patients affected by schizophrenia and controls
Whole-genome expression studies in peripheral tissues of patients affected by schizophrenia (SCZ) can provide new insights into the molecular basis of the disorder and innovative biomarkers that may be of great usefulness in the clinical practice. Recent evidence suggests that skin fibroblasts coul...
ORGANISM(S): Homo sapiens 
2015-02-17 | E-GEOD-62333 | biostudies-arrayexpress
ProteomicsDysregulation of the complement and coagulation cascade in treated schizophrenia and bipolar disorder patients
A better understanding of the proteomic profile after bipolar disorder (BD) and schizophrenia (SCZ) treatment, through monitoring its progression, may assist the development of novel therapeutic strategies with the ability to reduce or control possible side effects. In this study, proteomics analysi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-07 | MSV000086425 | MassIVE
TranscriptomicsmRNA Sequencing Reveals Altered Synaptic Vesicular Transport in Post-Mortem Cerebellum
Schizophrenia (SCZ) is a common, disabling mental illness with high heritability but complex, poorly understood genetic etiology. As the first phase of a genomic convergence analysis of SCZ, we generated 16.7 billion nucleotides of short read, shotgun sequences of cDNA from post-mortem cerebellar c...
ORGANISM(S): Homo sapiens 
2009-08-29 | E-GEOD-12297 | biostudies-arrayexpress
TranscriptomicsGenome-wide copy number variation in Chinese schizophrenia trios
To reveal the risk CNVs of SZ in Chinese population, we recrited and enrolled 100 Chinese family trios with a schizophrenia affected children and both of their father and mother. SZ was diagnosed according to DSM-IV criteria by two independent psychiatrists. There gDNA we screen the genome-wide CNV...
ORGANISM(S): Homo sapiens 
2021-10-01 | E-MTAB-8075 | biostudies-arrayexpress
UnknownPathways to prevention: the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ) Program.
Not available
S-EPMC12000314 | biostudies-literature
ProteomicsProteome landscape of schizophrenia in patient-derived cerebral organoids
We utilized patient-derived induced pluripotent stem cells (iPSCs) to generate 3D cerebral organoids to model neuropathology of Scz during this critical period. We discovered that Scz organoids exhibited ventricular neuropathology resulting in altered progenitor survival and disrupted neurogenesis. ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-17 | PXD027812 | Pride
Schizophrenia Ipsc Proteome Cerebral organoids Neuropathology 
GenomicMolecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)

This study is part of the Molecular Genetics of Schizophrenia (MGS) genome wide association study (GWAS) of 3,972 cases (2,686 EA and 1,286 AA) and 3,629 controls (2,656 EA and 973 AA) (analyzed sample remaining after quality control exclusions), comprised of European ancestry (EA) and African ...

phs000167 | dbGaP
ProteomicsMultimodal Proteomics reveals dysregulated secretion and ECM remodeling in schizophrenia patient iPSC-derived astrocytes
Astrocytes are increasingly implicated in the pathophysiology of schizophrenia (SCZ), yet how astrocytic dysfunction contributes to disease-relevant neuronal abnormalities remains unclear. Here, we use mass spectrometry–based proteomics to profile lysates (proteome) and secreted (secretome) proteins...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD075039 | Pride
Astrocytes Proteomics Ipsc Schizophrenia Protein secretion 
GenomicsMassively parallel functional dissection of schizophrenia associated non-coding genetic variants
Schizophrenia (SCZ) is a severe mental disorder affecting 1% of the world population. SCZ is characterized by an underlying genetic architecture that is highly polygenic. Genome wide association studies have identified thousands of genetic variants that are statistically linked to the disease. Howe...
EGAS00001007542 | EGA
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