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TranscriptomicsSystematic analysis of a human renal transcript dataset
Glomerular diseases account for the majority of cases with chronic renal failure. Several genes have been identified with key relevance for glomerular function. Quite a few of these genes show a specific or preferential mRNA expression in the renal glomerulus. To identify additional candidate genes ...
ORGANISM(S): Homo sapiens 
2010-07-19 | E-GEOD-21785 | biostudies-arrayexpress
TranscriptomicsTranscription analysis of E. coli processed at persistent and decreasing glucose limitation in a fed-batch cultivation
A time series of whole-genome transcription profiling of E. coli K-12 W3110 was performed to study the dynamic physiological response of E. coli K-12 W3110 to limited carbon conditions. cDNA from eight time intervals after glucose limitation, representing different stages of glucose depletion, along...
ORGANISM(S): Escherichia coli W3110 
2010-05-19 | E-GEOD-10307 | biostudies-arrayexpress
ProteomicsThe E3 ubiquitin ligase RNF115 regulates phagosome maturation and host response to infection
Phagocytosis is an essential process for the microbicidal function of professional phagocytes, in which phagosome maturation plays a critical role. Macrophage activation by interferons (IFN) increases their microbicidal activity, but delays phagosomal maturation. Here, we investigated the role of ub...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-20 | PXD026843 | Pride
Macrophage Phagosome Rnf115 Ubiquitin E3-ligase 
TranscriptomicsMiRNome and transcriptome aided pathway analysis in human regulatory T cells
Owing to their manifold immune regulatory functions, regulatory T cells (Treg) have received tremendous interests as targets for therapeutic intervention of diverse immunological pathologies or cancer. Directed manipulation of Treg will only be achievable with extensive knowledge about the intrinsic...
ORGANISM(S): Homo sapiens 
2014-05-23 | E-GEOD-54953 | biostudies-arrayexpress
ModelsChassagnole2002_Carbon_Metabolism
The model reproduces Figures 4,5 and 6 of the publication. The analytical functions for cometabolites Catp, Camp, Cnadph, and Cnadp slightly differ from the equations given in the paper. These changes were made in consultation with Dr. Christophe Chassagnole and are essential for reproducing the fi...
2024-09-02 | BIOMD0000000051 | BioModels
ProteomicsAn extended PAXT connection is required for turnover of nuclear polyadenylated RNA in human cells
Recruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA+) RNA is facilitated by the Poly(A) Tail eXosome Targeting (PAXT) connection. Besides its core dimer, formed by the exosome co-factor MTR4 and the ZFC3H1 protein, the PAXT connection remains poorly defined. By charact...
ORGANISM(S): Homo Sapiens (human) 
2019-10-31 | PXD016070 | JPOST Repository
TranscriptomicsExpression data of SW480 cells with TFAP2E overexpression and without TFAP2E (empty vector control)
AP2 transcription factors play important roles in development and cancer, we tried to clarify the role of the so far uncharacterised TFAP2E in colorectal cancer. We used GENE ST 1.0 Arrays to detail up and downregulated target genes of this AP-2 transcription factor. We used the ptarget mammalian ex...
ORGANISM(S): Homo sapiens 
2013-08-09 | E-GEOD-23698 | biostudies-arrayexpress
TranscriptomicsWhole genome transcription profiling of the L5 spinal nerve transection model of neuropathic pain in the rat, at different sequencing depths (RNA-Seq)
Poly(A) enriched RNA derived from the L5 DRG 7 days following L5-SNT and from naïve L5-DRG tissue was subjected to RNA-seq analysis at different sequencing depths 6 biological replicates (3 case – SNT subjected L5-DRG tissue, 3 control – naïve L5-DRG tissue). Each biological replicate was divided B4...
ORGANISM(S): Rattus norvegicus 
2014-01-07 | E-GEOD-53762 | biostudies-arrayexpress
TranscriptomicsPancreas-specific deletion of Ikba and RelA.
The NfkB-pathway is activated early during acute pancreatitis. We investigated the influence on gene expression of two pancreas-specific deletions interfering with NfkB-activation. Pancreata from 8 week old mice were prepared, RNA was isolated and Affymetrix microarray expression analysis was perfor...
ORGANISM(S): Mus musculus 
2012-12-02 | E-MTAB-886 | biostudies-arrayexpress
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