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TranscriptomicsComparison of spheroid-based 3-dimensional culture to monolayer of larynx carcinoma cell line HLaC78.
In vitro proliferation and/or invasion tests (such as MTT assay, Boyden Chamber Assay, Scratch assay) using established and well-characterized cell lines can provide easy and reproducible tools to investigate anti-tumour or anti-invasion agents ex vivo. However, in vivo cells in a tissue context int...
ORGANISM(S): Homo sapiens 
2016-03-11 | E-GEOD-67495 | biostudies-arrayexpress
TranscriptomicsInvolvement of the brain renin-angiotensin system in the effects of maternal separation
The postnatal development of the mouse is characterized by a stress hyporesponsive period (SHRP), where basal corticosterone levels are low and responsiveness to mild stressors is reduced. Maternal separation is able to disrupt the SHRP and is widely used to model early trauma. In this study we aime...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-14687 | biostudies-arrayexpress
UnknownThe alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome.
Not available
S-EPMC8358858 | biostudies-literature
TranscriptomicsBulk tissue RNA-seq of different sea lamprey (Petromyzon marinus) organs
Strand-specific RNA-seq libraries from different sea lamprey tissues (brain, heart, liver, kidney, ovary, testis) were produced in order to enhance the genome annotation for protein coding genes.
ORGANISM(S): Petromyzon marinus 
2021-12-13 | E-MTAB-11085 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of sea lamprey (Petromyzon marinus) brain regions
scRNA-seq was used in order to produce a cell type atlas of the larval and adult sea lamprey (Petromyzon marinus) brain. This resource enabled us to reveal the cell type composition and molecular organization of a representative of a lineage (i.e., the cyclostomes) that diverged from the rest of ver...
ORGANISM(S): Petromyzon marinus 
2021-12-13 | E-MTAB-11087 | biostudies-arrayexpress
TranscriptomicsIndividual susceptibility to chronic stress is modulated by AMPA receptor function
Chronic stress is a key risk factor for a variety of diseases, but the determinants of individual stress susceptibility are still unclear. Using a recently developed paradigm for chronic social stress in mice we identified animals that were resistant or susceptible to the persistent effects of chron...
ORGANISM(S): Mus musculus 
2010-10-25 | E-GEOD-11211 | biostudies-arrayexpress
UnknownProminent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes.
Not available
S-EPMC12795280 | biostudies-literature
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