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GenomicsActive STAT5 in CD8 T cells imprints a T-Bet-dependent Tc-1 program with repressed IL-6/ TGFb1 signaling leading to enhanced anti-tumor responses
CD8 T cells (TCs) expressing active STAT5 (STAT5CA) transcription factors were found to be superior to un-manipulated counterparts in their long-term persistence, capacity to infiltrate a tumor, thrive in its microenvironment and induce its regression. STAT5CA induced sustained expression of genes c...
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-41818 | biostudies-arrayexpress
TranscriptomicsMurine CD8+ T cells: in vitro-derived vs. thymocytes
Transcriptional profiling of mouse in-vitro derived CD8+ cells (obtained after culturing BM-HSCs isolated from B6 mice) with OP9-DL1 cells for 35 days were compared to CD8+ thymocytes isolated from 4-5 weeks old B6 mice. Our goal was to determine similarities and differences in gene expression prof...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-37669 | biostudies-arrayexpress
UnknownData of the effects of acetone fraction from Sechium edule (Jacq.) S.w. edible roots in the kidney of endothelial dysfunction induced mice.
Not available
S-EPMC5996300 | biostudies-literature
MetabolomicsNontargeted and targeted metabolomics measurements of abiotic stress responses in three-week-old Arabidopsis thaliana plants' rosette leaf tissue
Nontargeted and targeted metabolomics measurements of abiotic stress responses in three-week-old Arabidopsis thaliana plants' rosette leaf tissue for Col-0 wild type plants and double/triple knockout mutants of aquaporins (pip2;1 pip2;2 and pip2;1 pip2;2 pip2;4) treated with drought, heat at differe...
2017-07-17 | MTBLS355 | MetaboLights
UnknownXanthurenic acid binds to neuronal G-protein-coupled receptors that secondarily activate cationic channels in the cell line NCB-20.
Not available
S-EPMC3491036 | biostudies-literature
TranscriptomicsSex-specific effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene x environment interactions
prenatal stress response, genetic modification Background: Prenatal stress (PS) exposure has been shown to increase the risk for emotional disorders in later life. Furthermore, the serotonin transporter (5-HTT) genotype is suggested to exert a modulating effect on the association between early life ...
ORGANISM(S): Mus musculus 
2011-12-12 | E-GEOD-26025 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of different developmental stages of a novel natural isolate of the model organism Ashbya gossypii
This is a transcriptome analysis of a novel A. gossypii natural isolate at different developmental stages. Individual transcription profiles were developed from spores to bipolar germlings (time frame 9 h) and to very fast growing hyphae at the border of colony growing with maximal speed on plates (...
ORGANISM(S): Ashbya gossypii 
2011-01-31 | E-MEXP-1955 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of model organism Ashbya gossypii at different life cycle stages
In contrast to most filamentous fungi, A. gossypii displays
a very simple haploid life cycle. This is a transcriptome analysis
of A. gossypii at different developmental stages. Individual transcription profiles
were developed from spores to bipolar germlings (time
frame 9 h), from bipo...
ORGANISM(S): Ashbya gossypii 
2011-01-31 | E-MEXP-1945 | biostudies-arrayexpress
TranscriptomicsPrenatal stress-induced programming of genome-wide promoter DNA methylation in 5-Htt deficient mice
The serotonin transporter (5-HTT) gene-linked polymorphic region has been suggested to play a modulatory role in mediating the effects of early-life stress on psychopathology rendering carriers of the low-expression short (s)-allele more vulnerable to environmental adversity in later life. Here we a...
ORGANISM(S): Mus musculus 
2014-11-18 | E-GEOD-51634 | biostudies-arrayexpress
UnknownFunctional human GRIN2B promoter polymorphism and variation of mental processing speed in older adults.
Not available
S-EPMC5425128 | biostudies-literature
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