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ProteomicsUBR5 Forms Ligand-Dependent Complexes on Chromatin to Regulate Nuclear Hormone Receptor Stability
Nuclear hormone receptors (NRs) are ligand-binding transcription factors that are widely targeted therapeutically. Hormone binding triggers NR activation and their subsequent proteasomal degradation through unknown ligand-dependent ubiquitin ligase machinery. NR degradation is therapeutically releva...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040953 | Pride
Nuclear receptors Ubr5 Degradation Hormones Chromatin 
TranscriptomicsYeast (Saccharomyces cerevisiae) Overexpression suppression study
To address the mechanisms of suppression, we analyzed time course of mRNA expression of four suppressed smc2-8 mutant strains. We addressed the question of genomic robustness by systematically screening genomic open reading frames, when induced for high-level expression, for their ability to suppres...
ORGANISM(S): Saccharomyces cerevisiae 
2011-09-20 | E-GEOD-24266 | biostudies-arrayexpress
MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
UnknownContinent-wide differentiation of fitness traits and patterns of climate adaptation among European populations of <i>Drosophila melanogaster</i>.
Not available
S-EPMC12448211 | biostudies-literature
MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
UnknownThe discovery, distribution, and diversity of DNA viruses associated with Drosophila melanogaster in Europe.
Not available
S-EPMC8363768 | biostudies-literature
UnknownDrosophila Evolution over Space and Time (DEST): A New Population Genomics Resource.
Not available
S-EPMC8662648 | biostudies-literature
UnknownAltered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study.
Not available
S-EPMC6986984 | biostudies-literature
UnknownAbdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome.
Not available
S-EPMC4122779 | biostudies-literature
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