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The Uncharacterized Protein Family 0016 (UPF0016) is conserved throughout evolution. In humans, the member TMEM165 is a putative Golgi localized Ca2+ and/or Mn2+ transporter. Genes encoding UPF0016 proteins are also present in many bacteria, including the cyanobacteria Synechocystis (MNX/SynPAM71), ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-04-20 | PXD022763 | Pride
Protein-protein interactions within complexes and networks are often dynamic and their elucidation remains a challenging task. Here, we show on the example of the proteolytic ClpXP complex the power of combined chemical cross-linking and mass-spectrometry to capture transient binding interactions wi...
ORGANISM(S): Homo sapiens (Human) Escherichia coli Staphylococcus aureus 
2018-11-21 | PXD009224 | Pride
Human renal proximal tubule cells (RPTEC/TERT1) were exposed to one of two nephrotoxic chemicals, ochratoxin A (OA) or potassium bromate (KB), or a vehicle control (CT). The exposure regime was a repeated dosing every 24h for 5 days followed by chemical washout and 3 days of recovery with medium ren...
ORGANISM(S): Homo sapiens 

Flavivirus infection is tightly connected to host lipid metabolism. Here, we performed shotgun lipidomics of cells infected with neurotropic Zika, West Nile and tick-borne encephalitis viruses, as well as dengue and yellow fever virus. Early in infection specific lipids accumulated, e.g., neutral...

2025-02-24 | MTBLS11030 | MetaboLights
Expression data from 22 human myotubes (7 healthy controls, 4 Dysferlinopathy (DYSF), 4 Caveolinopathy 3 (CAV3), 4 Facioscapulohumeral muscular dystrophy(FSHD) and 3 Four and a half LIM 1 protein deficiency FHL1).cDNA microarray data showed that cyclin A1 levels are specifically elevated in FSHD vs...
ORGANISM(S): Homo sapiens 
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