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UnknownCross-Sectional Comparison of Sleep-Disordered Breathing in Native Peruvian Highlanders and Lowlanders.
Not available
S-EPMC5361758 | biostudies-literature
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
ProteomicsCharacterization of a new variant of SERPINA1 Gene Causing Alpha-1 Antitrypsin Deficiency
Alpha 1-Antitrypsin Deficiency (AATD) is a rare genetic disorder caused by mutations in the SERPINA1 gene, which encodes the Alpha 1-Antitrypsin (AAT) protein. Individuals carrying pathogenic SERPINA1 variants are predisposed to lung and liver damage. The most common AATD-associated SERPINA1 alleles...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD060960 | Pride
Aatd Alpha 1-antitrypsin deficiency Liver 
TranscriptomicsTranscription profiling of mouse heart from cardiac-specific conditional knockout deletion of menage-a-trios-1 (MAT1)
The Cdk7/cyclin H/menage-a-trois 1 (MAT1) heterotrimer has proposed functions in transcription as the kinase component of basal transcription factor TFIIH and is activated in adult hearts by hypertrophic pathways. Using cardiac-specific Cre, we ablated MAT1 in myocardium. Despite reduced Cdk7 activi...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-6662 | biostudies-arrayexpress
TranscriptomicsTMPRSS2 Influences Prostate Cancer Metastasis
TMPRSS2 is an androgen-regulated cell surface serine protease expressed predominantly in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate cancers and in the majority of human prostate cancer metastasis. Through the generation of mouse models with a targeted deletion ...
ORGANISM(S): Mus musculus 
2014-09-09 | E-GEOD-58822 | biostudies-arrayexpress
ProteomicsCross-linking of the microtubule binding N-terminal domain of the companion of cellulose synthase 1 protein (CC1∆C223) from Arabidopsis thaliana with tubulin
In this study, we use Cross-linking Mass Spectrometry to identify the interaction sites of the microtubule binding N-terminal domain of the companion of cellulose synthase 1 protein (CC1∆C223) from Arabidopsis thaliana with tubulin. We consistently detected four cross-linked peptides of CC1∆C223 to ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2019-01-08 | PXD009260 | Pride
Arabidopsis thaliana Cx-ms Cross-linking Microtubule Tubulin 
ProteomicsIdentification of RNA chaperones by gradient profiling in the Lyme disease spirochete, Borrelia burgdorferi
RNA-binding proteins (RBPs) play key roles in regulating gene expression in bacteria. However, relatively few RBPs have been discovered and characterized in Borrelia (Borreliella) burgdorferi, the causative agent of Lyme disease. We utilized gradient profiling to identify putative RBPs that co-sedim...
ORGANISM(S): Borreliella burgdorferi 
2026-06-29 | PXD068462 | Pride
Lyme disease Borrelia burgdorferi Rna chaperone Rna-binding protein 
GenomicsNucleosomes are context-specific, H2A.Z modulated barriers to RNA polymerase
Nucleosomes are barriers to transcription in vitro, however, their effects on RNA polymerase in vivo are unknown. Here we describe a simple and general strategy to comprehensively map the positions of elongating and arrested RNA Polymerase II (RNAPII) at nucleotide resolution. Our results suggest th...
ORGANISM(S): Drosophila melanogaster 
2014-03-06 | E-GEOD-49106 | biostudies-arrayexpress
TranscriptomicsProlyl hydroxylase PHD3 is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
Neutrophils were isolated form peripheral blood of wildtype and Phd3 null mice, cultured for 4 hours in hypoxia (3% O2) and micro array analysis performed The aim of the present study is to identify the mechanism by which phd3 is required for the hypoxia mediated survival of neutrophils Murine perip...
ORGANISM(S): Mus musculus 
2011-02-08 | E-GEOD-26023 | biostudies-arrayexpress
TranscriptomicsGenomic Signatures of Metastasis in Prostate Cancer
Background: Metastases result in 90% of all cancer deaths. Prostate cancer primary tumors evolve to become metastatic through selective alterations, such as amplification and deletion of genomic DNA. Methods: Genomic DNA copy number alterations were used to develop a gene signature that meas...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-27105 | biostudies-arrayexpress
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