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ProteomicsProteomic signature of NPC1 KO microglia from conditional KO mice
Niemann-Pick type C (NPC) disease is a rare neurodegenerative disorder mainly caused by autosomal recessive mutations in Npc1 which result in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is one of the prominent pathological features, consequences of NPC1 loss on microglial ...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-09 | PXD019452 | Pride
Mouse Niemann-pick disease Microglia Neurodegeneration 
TranscriptomicsAGO 1 IMMUNOPRECIPITATION MICROARRAYS
Little is known about the contribution of translational control to circadian rhythms. To address this issue and in particular translational control by microRNAs (miRNAs), we knocked down the miRNA biogenesis pathway in Drosophila circadian tissues. In combination with an increase in circadian-media...
ORGANISM(S): Drosophila melanogaster 
2009-08-31 | E-GEOD-17627 | biostudies-arrayexpress
GenomicsTranscriptional regulation by H3K122 acetylation in the lateral surface of the histone octamer
We characterize the acetylation of H3K122 for the first time. Towards this we mapped the genomic distribution of H3K122Ac, identified the enzyme introducing H3K122Ac, and addressed the functional contribution H3K122Ac to transcription. We found that H3K122Ac is associated with chromatin marks and ge...
ORGANISM(S): Homo sapiens 
2013-02-14 | E-GEOD-35954 | biostudies-arrayexpress
UnknownAn adapted protocol to derive microglia from stem cells and its application in the study of CSF1R-related disorders.
Not available
S-EPMC10996091 | biostudies-literature
ProteomicsProteomic signature of NPC1 KO microglia
Niemann-Pick type C (NPC) disease is a rare neurodegenerative disorder mainly caused by autosomal recessive mutations in Npc1 which result in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is one of the prominent pathological features, consequences of NPC1 loss on microglial ...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-09 | PXD019447 | Pride
Npc1 Niemann-pick disease Microglia Neurodegeneration 
ProteomicsTET1 interactome in mESCs (via ChIP-MS)
Precise regulation of DNA methylation in mammals is critical for genome stability and epigenetic regulation. The discovery of the ten-eleven translocation (TET) proteins catalyzing the oxidation from 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcyto...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-31 | PXD028850 | Pride
Epigenetics Tet1 Mouse embryonic stem cells Dna methylation 
ProteomicsProteomic analysis of monocyte derived macrophages from Niemann-Pick disease type C patients
Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by mutations in Npc1, resulting in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is a prominent pathological feature, direct consequences of NPC1 loss on microglial function remain uncharacterized...
ORGANISM(S): Homo sapiens (Human) 
2021-02-09 | PXD020659 | Pride
Npc Macrophage Lysosomal storage disorder 
TranscriptomicsRNA-seq of D. melanogaster S2 cells upon depletion of dCoREST and its interacting partners compared to control
RNAi KD of dCoREST, dLSD1, dL(3)mbt, dLint-1, dG9a and EGFP (control) followed by determination of gene transcription changes by RNA-seq
ORGANISM(S): Drosophila melanogaster 
2019-01-01 | E-MTAB-7440 | biostudies-arrayexpress
ProteomicsDissection of TET1 catalytic and non-catalytic functions reveals DNA demethylation independent gene and ERV regulation
Surveillance of DNA methylation in mammals is critical for genome stability and epigenetic regulation. The discovery of the ten-eleven translocation (TET) proteins catalyzing the oxidation from 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-11 | PXD028566 | Pride
Methylation Acetylation Tet1 Histone ptms 
TranscriptomicsDAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage [N2, daf-2, daf-16, daf-2;daf-16]
Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature aging. It remains poorly understood how DNA damage responses function during organismal development and maintain tissue functionality when DNA damage accumulates wi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-18 | E-GEOD-51162 | biostudies-arrayexpress
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