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GenomicsPromoter capture mESC and fetal liver
Genome organization influences transcriptional regulation by facilitating interactions between gene promoters and distal regulatory elements. To analyse distal promoter contacts we used Capture Hi-C (CHi-C) to enrich for promoter-interactions in HiC libraries from mouse ESC and E14.5 fetal liver. Pl...
ORGANISM(S): Mus musculus 
2015-02-01 | E-MTAB-2414 | biostudies-arrayexpress
TranscriptomicsPromoter Capture Hi-C of mouse ESC and TSC
Chromatin organisation of trophoblast stem cells (TSC) were compared with that of embryonic stem cells (ESC). The method enriches Hi-C libraries, to detect promoter interactions at restriction fragment level. We prepared Hi-C libraries from TSC and ESC (serum grown) samples and enriched them with a ...
ORGANISM(S): Mus musculus 
2018-09-05 | E-MTAB-6585 | biostudies-arrayexpress
TranscriptomicsSingle cell Hi-C reveals cell-to-cell variability in chromosome structure
Large-scale chromosome structure and spatial nuclear arrangement have been linked to control of gene expression and DNA replication and repair. Genomic techniques based on chromosome conformation capture assess contacts for millions of loci simultaneously, but do so by averaging chromosome conformat...
ORGANISM(S): Mus musculus 
2013-09-26 | E-GEOD-48262 | biostudies-arrayexpress
TranscriptomicsComparison of Hi-C results using in-solution versus in-nucleus ligation
Chromosome conformation capture (3C) and derivative (4C, 5C and Hi-C) methods employ ligation of diluted cross-linked chromatin complexes, intended to favor proximity-dependent, intra-complex ligation. We previously described an alternative Hi-C protocol with ligation in preserved nuclei rather than...
ORGANISM(S): Mus musculus 
2015-08-12 | E-GEOD-70181 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of mouse erythroid tissue with RNAPII-S5P ChIP e4C to identify spatial interactomes of mouse globin genes, using alpha and beta globin genes as baits
RNAPII-S5P ChIP e4C was performed on mouse erythroid tissue, using the alpha and beta globin genes as baits
ORGANISM(S): Mus musculus 
2009-12-01 | E-TABM-822 | biostudies-arrayexpress
Genomicsena-DATASET-ICR-PTGT-05-02-2015-11:21:41:591-6 - samples
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.
EGAD00001001243 | EGA
GenomicsCapture Hi-C identifies the chromatin interactome of colorectal cancer risk loci
Multiple regulatory elements distant to their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functi...
EGAS00001001085 | EGA
GenomicsMolecular and Population Genetics (MPG) research at ICR DAC agreement
Data Access Committee EGAC00001000303
EGAC00001000303 | EGA
GenomicsPromoter capture GM12878 CD34
Genome organization influences transcriptional regulation by facilitating interactions between gene promoters and distal regulatory elements. To analyse distal promoter contacts we used Capture Hi-C (CHi-C) to enrich for promoter-interactions in a HiC lib
ORGANISM(S): Homo sapiens 
2015-03-01 | E-MTAB-2323 | biostudies-arrayexpress
TranscriptomicsCHiCAGO: Robust Detection of DNA Looping Interactions in Capture Hi-C data
Capture Hi-C (CHi-C) is a state-of-the art method for profiling chromosomal interactions involving targeted regions of interest (such as gene promoters) globally and at high resolution. Signal detection in CHi-C data involves a number of statistical challenges that are not observed when using other ...
ORGANISM(S): Mus musculus 
2016-05-18 | E-GEOD-81503 | biostudies-arrayexpress
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