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ProteomicsCaMKII Cardiac Phosphoproteome
We investigated the differential phosphoproteome of the mouse heart after isoproterenol stimulus of the AC3-I and AC3-C mice. The former is a model of specific in vivo CaMKII inhibition by a transgenically expressed peptide, whereas the latter is a transgenic mouse expressing a control peptide. Da...
ORGANISM(S): Mus musculus (Mouse) 
2013-08-02 | PXD000174 | Pride
Mouse heart In vivo Camkii targets Phosphoproteomics Transgenic model Inhibition 
ProteomicsA Proteomics Approach to Identify New Cardiac Intercalated Disc Proteins
Synchronous beating of the heart is dependent on the efficient functioning of the cardiac intercalated disc (ID). The ID is composed of a complex protein network enabling electrical continuity and chemical communication between individual cardiomyocytes. Off late a lot of studies have shed light on ...
ORGANISM(S): Rattus rattus (Black rat) 
2016-04-12 | PXD000947 | Pride
Lc-msms Heart Rat Intercalated disc 
ProteomicsAlterations in the Interactome of Serine/Threonine Protein Phosphatase Type-1 in Atrial Fibrillation Patients
Objectives: To test the hypothesis that serine/threonine protein phosphatase type-1 (PP1) is dysregulated in paroxysmal atrial fibrillation (pAF) at the level of its regulatory subunits (R-subunits). Background: AF is the most common sustained cardiac arrhythmia yet current pharmacologic treatment i...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2015-03-30 | PXD000697 | Pride
Human Label-free quantification Q-exactive Mouse Protein phosphatase 1 Paroxysmal atrial fibrillation Ltq-orbitrap elite 
OtherHuntingtin associated protein (HAP1) is a cGMP-dependent kinase anchoring protein (GKAP), specific for the cGMP-dependent protein kinase Iβ isoform.
Data from ProteomeXchange, PXD ID: PXD001434. Published as part of J Biol Chem. 2015 Feb 4. pii . From the Abstract: {{i}} ... Here, we extend on this cAMP-based chemical proteomics approach, employing competitive concentrations of free cyclic nucleotides to isolate each kinase and its secondary in...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320007631 | GPMDB
Resource Reanalysis 
ProteomicsHuman cTnT fragmentation in serum
Cardiac troponin T (cTnT) is a highly cardiospecific protein commonly used in the diagnosis of acute myocardial infarction (AMI), but is subject to proteolytic degradation upon its release in the circulation. In this study, a targeted mass spectrometry assay was developed to detect peptides which ar...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080749 | MassIVE
ProteomicsChymotrypsin_180min10xMSMS_LTQ_Orbi_Classic
Chymotrypsin_180min10xMSMS_LTQ_Orbi_Classic
ORGANISM(S): Saccharomyces Cerevisiae 
2012-12-31 | PAe004037 | PeptideAtlas
ProteomicsChymotrypsin_180minx10msms_CID_LTQ_Orbi_Velos
Chymotrypsin_180minx10msms_CID_LTQ_Orbi_Velos
ORGANISM(S): Saccharomyces Cerevisiae 
2012-12-31 | PAe004036 | PeptideAtlas
ProteomicsLysN_4h_180minx10msms_LTQ_Orbi_Classic
LysN_4h_180minx10msms_LTQ_Orbi_Classic
ORGANISM(S): Saccharomyces Cerevisiae 
2012-12-31 | PAe004034 | PeptideAtlas
ProteomicsLysC_180minx10msms_CID_LTQ_Orbi_Velos
LysC_180minx10msms_CID_LTQ_Orbi_Velos
ORGANISM(S): Saccharomyces Cerevisiae 
2012-12-31 | PAe004032 | PeptideAtlas
ProteomicsLysC_180min10xMSMS_LTQ_Orbi_Classic
LysC_180min10xMSMS_LTQ_Orbi_Classic
ORGANISM(S): Saccharomyces Cerevisiae 
2012-12-31 | PAe004028 | PeptideAtlas
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