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TranscriptomicsZebrafish embryos exposed to the model hedgehog pathway inhibitor cyclopamine, as well as to the potential hedghog pathway disrupters SANT-2 and GANT-61.
The hedgehog (Hh) signaling pathway is important for various developmental processes during embryogenesis and for homeostasis of adult tissue in vertebrates. Aberrant signaling results in severe birth defects and malignancies, respectively. The small molecules SANT-2 and GANT-61 were identified as p...
ORGANISM(S): Danio rerio 
2011-09-30 | E-GEOD-29357 | biostudies-arrayexpress
ProteomicsChlamydomonas reinhardtii Mannosidase 1A and Xylosyltransferase1A N-glycosylation LC/MS-MS
We have identified insertional mutants of mannosidase 1A and xylosyltransferase 1A in Chlamydomonas reinhardtii. Mass spectrometric analyses of intact N-glycopeptides revealed that disruption of the genes altered the N-glycan composition of the alga (in single as well as double mutant). In contrast ...
ORGANISM(S): Chlamydomonas reinhardtii 
2018-02-27 | PXD005254 | Pride
Chlamydomonas reinhardtii N-gylcoproteomics Lc-ms/ms 
ProteomicsLabel-free quantitative proteomic analysis of DNA methyltransferase mutants of the cyanobacterium Synechocystis sp. PCC 6803 – Analysis of the membrane-enriched fraction
Total protein and membrane-enriched fractions of Synechocystis sp. PCC 6803 wild type (WT) and mutant strains affected with inactivated DNA methyltransferase genes were analyzed by LC-HDMSE. The mutation of the DNA methyltransferase gene sll0729 encoding M.Ssp6803II initially led to a strong phenoty...
ORGANISM(S): Synechocystis sp. (strain PCC 6803 / Kazusa) 
2019-06-26 | PXD012698 | Pride
Dna methyltransferase Hdmse Label-free quantification Suppressor mutants Synechocystis sp. pcc 6803 
ProteomicsLabel-free quantitative proteomic analysis of DNA methyltransferase mutants of the cyanobacterium Synechocystis sp. PCC 6803 – Analysis of total protein extracts
Total protein and membrane-enriched fractions of Synechocystis sp. PCC 6803 wild type (WT) and mutant strains affected with inactivated DNA methyltransferase genes were analyzed by LC-HDMSE. The mutation of the DNA methyltransferase gene sll0729 encoding M.Ssp6803II initially led to a strong phenoty...
ORGANISM(S): Synechocystis sp. (strain PCC 6803 / Kazusa) 
2019-06-26 | PXD012751 | Pride
Dna methyltransferase Hdmse Label-free quantification Suppressor mutants Synechocystis sp. pcc 6803 
TranscriptomicsExploring the potential of a Functional Gene Array (FGA) for fluvial biofilms
Microarrays offer a comprehensive tool for a system-wide analysis of cell functioning based on the simultaneous detection of the activity of thousands of genes. While transcriptome analyses are usually related with the study of gene expression and regulation within single species in laboratory exper...
ORGANISM(S): Scenedesmus vacuolatus 
2012-12-31 | E-GEOD-22496 | biostudies-arrayexpress
MetabolomicsHigh-throughput carotenoid profiling using multivariate curve resolution (Stability of isoprenoids in grape extract)
We present automated data analysis of high throughput high-performance liquid chromatography with diode array detection (HPLC-DAD) data using multivariate curve resolution. This technique provides spectra and elution profiles of all UV-Vis active compounds present in the mixture. The specifics of us...
2014-07-01 | MTBLS85 | MetaboLights
ProteomicsChlamydomonas reinhardtii quantification of Mannosidase 1A and Xylosyltransferase1A
We have identified insertional mutants of mannosidase 1A and xylosyltransferase 1A in Chlamydomonas reinhardtii. To verify a knockout/knockdown of the enzymes in the insertional mutant strains, PRM measurements were performed. Mass spectrometric analyses of intact N-glycopeptides revealed that disru...
ORGANISM(S): Chlamydomonas reinhardtii 
2018-02-27 | PXD005257 | Pride
Chlamydomonas reinhardtii N-glycosylation Quantification 
UnknownProbabilistic modelling of developmental neurotoxicity based on a simplified adverse outcome pathway network.
Not available
S-EPMC8857173 | biostudies-literature
UnknownDevelopment of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality.
Not available
S-EPMC11106268 | biostudies-literature
GenomicsNINDS-Genome-Wide Genotyping in Parkinson's Disease: First Stage Analysis and Public Release of Data

Epidemiological studies have estimated a cumulative prevalence of PD of greater than 1 per thousand. When prevalence is limited to senior populations, this proportion increases nearly 10-fold. The estimated genetic risk ratio for PD is approximately 1.7 (70% increased risk for PD if a sibling...

phs000089.v3.p2 | EGA
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